Hit Profiling / Lead Optimization Assays
Finalize hits and characterize compounds with ADME and toxicity assays. Compounds must have suitable pharmacokinetics to proceed with in vivo models and clinical trials. Profiling or characterization assay readouts can range from detailed microscopy analyses, changes in electrochemical gradients across membranes, functional assays with flow cytometry or LC/MS, to determine how differences at the atomic level can affect kinetics of each compound.
The life sciences companies of Danaher offer the following analytical and data management solutions to help with your screening:
- Molecular Devices ImageXPress HT.ai High Content Imaging System
- Molecular Devices FLIPR Penta High Throughput Cellular Screening System
- Beckman Coulter Life Sciences Vi-CELL BLU Cell Viability Analyzer
- Beckman Coulter Life Sciences CytoFLEX Flow Cytometer
- Molecular Devices SpectraMax iD5 Plate Reader
- Leica Microsystems Stellaris Confocal Microscope
- IDBS Polar Biopharma Lifecycle Management software
- SCIEX Echo MS System
- SCIEX ZenoTOF 7600 System
- Genedata Biopharma Platform software