Our patch clamps are versatile instruments used in electrophysiology to study ion channel behavior. Electrophysiology is applied to various cell types, engineered to overexpress single ion channels. These patch clamp solutions aid in understanding ion channel behavior in normal and disease conditions and the effects of various drugs, ions, or analytes on these conditions.

We offer complete solutions for patch-clamping, covering whole-cell patch-clamp, extracellular, and single-channel recordings, which include amplifiers, digitizers, software, and accompanying accessories. We can provide the perfect amplifier choice for your specific application, ensuring the highest quality data acquisition. Our experienced teams work closely with customers, offering remote and on-site product demonstrations, webinars, and other resources to assist in overcoming your research obstacles.

Features

Essential features of our Patch Clamp Instruments

• Our patch-clamp system efficiently eliminates 50/60 Hz line-frequency interference on up to four channels simultaneously with a simple software activation.
• The software includes various modules and tools that streamline setup and support parameter automation and features an enhanced protocol editor, allowing for longer and more intricate protocols reducing setup time.
• Our extensive range of amplifiers ensures we can match the perfect solution to your specific application, guaranteeing the highest quality data.
• The gap-free mode permits command and digital outputs to be programmed continuously during recording, enhancing protocol design and enabling automatic actions within the protocol.
• Advanced modules facilitate automatic measurements of action potentials and population spikes.
• The new Batch Analysis feature enables the analysis of multiple datasets using the same macro, saving time and ensuring consistent analysis for each dataset.

Applications

Applications of our Patch-Clamp Systems

• Our patch clamps are used to study the impact of ion channel function in neuronal communication, providing insights into how ion channels influence normal and abnormal neurological processes, which can be valuable for understanding conditions like epilepsy or neurodegenerative diseases.
• They are utilized to investigate the precise generation and propagation of action potentials in neurons, enabling researchers to understand the intricacies of neuronal signaling and study various aspects of neurophysiology, including ion channel function and the effects of drugs or genetic mutations on neuronal excitability.
• Our patch clamp solutions help study the behavior of single ion channels in a cell membrane, offering detailed insights into ion channel kinetics and conductance. These are critical for understanding ion channelopathies, drug interactions, and the functioning of various ion channels in neurons and other excitable cells.
• The whole cell configuration is crucial in studying cardiac myocytes to assess and manipulate the transmembrane voltage, thereby enabling detailed investigations of ion channel currents and cardiac electrophysiology, which is vital for understanding arrhythmias, drug effects, and cardiac disorders.
• The patch clamp technique is extensively employed by researchers worldwide to explore various aspects of neurobiology and cellular physiology, including the investigation of how amyloid beta peptides affect ion channels in Alzheimer's disease, the evaluation of signaling mechanisms involved in memory and recall processes in the brain, and the study of the molecular mechanisms of inhibitory synapses.

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