Echo® MS+ Systems
Combining high data quality and high-throughput analysis
When the quantity of samples is your challenge, break through with the Echo® MS+ system. The Echo® MS+ system gives you high-quality data, analytical flexibility and high sample throughput so you can make informed decisions, today. With sampling rates of up to 1 sample per second, results can be generated on the same day. The Echo® MS+ system is a complete solution that removes bottlenecks in high-throughput analytical workflows, from sample preparation to data reporting.
Choose the right Echo® MS+ system for your laboratory
The Echo® MS+ system is available in two configurations:
- Echo® MS+ system with SCIEX Triple Quad 6500+ system
- Echo® MS+ system with ZenoTOF 7600 system offering you the flexibility to meet the needs of your laboratory.

Learn how contactless ejection works
The Echo® MS+ system addresses challenges, such as sample preparation and analysis time, in qualitative and quantitative mass spectrometry analysis.
Redefining high-throughput quantification workflows.
Quality
Deliver high-quality data, minimize sample handling and eliminate carry over with contactless acoustic ejection sampling. Retain the precise, information-rich data needed to make informed decisions about your sample
Precision
Achieve unparalleled standards of quantitation and qualification, at speed. The Echo® MS+ system provides consistency and precision in challenging matrices. Its high specificity enables confidence in results, and both decreases the need for re-runs and saves on reagent costs when compared to other technologies.
Speed
Conquer throughput barriers and decrease overall turnaround time with sampling speeds of up to 1 sample per second. Screen substrate and product simultaneously and reduce the number of analytical steps in your process.
THE SYSTEM
Explore the Echo® MS+ system

BENEFITS
Redefining high-throughput quan/qual workflows
01. High-quality data
The Echo® MS+ system is compatible with either the SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system for trusted mass spectrometry performance.
02. Contactless sampling
Sample ejection allows for rapid sampling and reduced carryover.
03. Designed for automation
The system is compatible with robotic automation systems—automating steps such as sample preparation, plate preparation, plate loading/unloading, and plate submission for analysis.
04. Longer operational robustness
The port wash allows for cleaning the electrode assembly between sample plates, increasing the number of ejections that generate high quality data before you need to manually replace consumables.
05. Method flexibility
The new features of SCIEX OS software allow:
- Enhanced solvent and additive options for analytical flexibility
- Data acquisition modes to enable robust quantitative and qualitative capability
- The ability to analyze samples directly from a DMSO matrix
Echo® MS+ system walkthrough
01. Acoustic ejection method
Method setup is both simple and fast. With data acquisition taking as little as 1 sample per second, you can quickly test many options for ideal settings.
02. Mass spectrometer method
The MS method is similar to standard MS systems, with parameters such as mass range or MRM transition needing to be defined. SCIEX OS software users will be familiar with this step.
03. Results
Acquire and process your data in SCIEX OS software, simplifying your workflows and empowering swift, well-informed decision-making.
04. Data collection
See the process from beginning to end
-
How AEMS takes your analysis to the new level
The Echo® MS+ system uses Acoustic Ejection Mass Spectrometry (AEMS). Samples are placed into compatible microtiter plates that are held in the Echo® MS+ system autosampler. Here, sound energy is applied to the bottom of each well individually. The sound energy causes reproducible droplets to be ejected from the well for capture in a carrier solvent of the OPI for dilution and transfer to the mass spectrometer source. From this point, the diluted sample is ionized using conventional electrospray ionization, making it ready for detection.
Related topics
ZenoTOF 7600 system
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
SCIEX Triple Quad 6500+ system
Delivering a balance of speed, performance, and sensitivity for your most challenging analytes.
High-throughput mass spectrometry
Screen thousands of candidates for desirable drug properties and process data with confidence, faster. Get the information you need to make go/no-go decisions quickly in the drug discovery phase of your work.