ImageXpress® HCS.ai High-Content Screening System

Modular and intuitive for optimal versatility

The ImageXpress HCS.ai system features a modular design and a wide array of customizable configuration options to meet your current needs and on-site upgrades to match your future requirements. The newly upgraded MetaXpress^® Acquire software is an intuitive solution for users of all experience levels, providing direct access to reliable and insightful data.

Higher quality images and superior data analysis for deeper insights

Acquire high-quality images across a vast range of assay types, obtain exceptional image quality from your 3D samples, and unlock new discoveries with AI-powered IN Carta^® Image Analysis Software.

Faster acquisition for accelerated high-throughput workflows

Boost lab productivity by imaging more plates in less time and simplifying the learning curve for new users. A new, automation friendly design enables you to integrate easily into automated workflows for faster, more reliable results.

Key Features of ImageXpress HCS.ai High-Content Screening System

Multiple imaging modes

The system offers brightfield label-free imaging, widefield and confocal fluorescent imaging.

Automated water immersion objective technology option

Offers greater image resolution and sensitivity with up to 4x increase in signal, which leads to lower exposure times.

Streamlined upgrade pathway

The modular design enables additional capabilities to be easily added to your system, allowing easy upgrades as your needs evolve.

Exclusive AgileOptix^™ spinning disk technology

Provides increased sensitivity with specially designed optics, high-powered laser illumination, and sCMOS sensor. Swappable disk geometries provide flexibility between speed and resolution.

High-intensity laser light source option

The option of laser illumination enables you to capture images faster with shorter exposure times and multiplex your experiments with 7 lasers and 8 imaging channels.

Magnification changer option

Get access to 12 magnifications within a single configuration, including high NA (Numerical Aperture) and ELWD (Extra-Long Working Distance) options.

MetaXpress^® Acquire Software

The MetaXpress^® Acquire acquisition package streamlines complex workflows—new users can get started quickly, whereas advanced users can leverage its flexibility to create optimized protocols.

AI-powered IN Carta^® image analysis software

Leverages machine-learning to improve the accuracy and robustness of high-content image analysis, delivering data insights that other technologies miss. Reduces the complexity of image analysis with intuitive guided workflows in a modern user interface.

The ImageXpress HCS.ai system empowers you to perform a wide range of assays on more physiologically relevant cell models—enabling deeper insights and more impactful discoveries. Capture stunning, high-quality images from long-term live-cell experiments, 3D models, and multiplexed phenotypic screens using the intuitive MetaXpress^® Acquire software. Then accelerate your analysis with AI-powered IN Carta^® Image Analysis Software, designed to decode even the most complex biological questions with speed and precision.

Applications of ImageXpress HCS.ai High-Content Screening System

• 3D Cell Imaging and Analysis
• COVID-19 and Infectious Disease Research
• Cell Painting
• Cells in Extracellular Matrices
• Disease Modeling
• Drug Discovery & Development
• Live cell imaging
• Neurite Outgrowth / Neurite Tracing
• Oncology - Cancer Research
• Organ-on-a-Chip
• Organoids
• Spheroids
• Stem Cell Research
• T-cells and 3D cell models for immunotherapy
• Toxicology