Plasmid Analysis for AAV Vectors - Automation, Analytical and Digital Solutions
It is important to analyze plasmids for critical structural elements that may have an impact on the upstream and downstream processing of AAVs. Several parameters and testing methods are used to achieve this, including residual host DNA/RNA, endotoxin, mycoplasma, sterility, purity and sequencing. Additionally, determining plasmid titers is essential.
Molecular Devices SpectraMax plate readers provide imaging readouts for various QC assays such as DNA quantification, sample sterility, endotoxin and mycoplasma screening. Molecular Devices and Beckman Coulter Life Sciences offer integrated workflow solutions to cover assay steps.
It is crucial to perform structural quality assessments that check for coiling, perform fragment analysis, and detect isoforms and host cell DNA/RNA. The SCIEX PA800 Plus system uses capillary electrophoresis with integrated analysis software to uncover these parameters.
NGS library preparation can be fully automated using the Beckman Coulter Life Sciences Biomek i-Series Automated Workstation and the Beckman Coulter Life Sciences Echo Acoustic Liquid Handler, which sustainably minimizes reagent volume consumption. Genedata's Selector software can analyze and share your findings across the organization.
Ensure all plasmid analysis assays and findings are documented in the IDBS Polar Biopharma Lifecycle Management platform for streamlined reporting.
Plasmid Analysis Products
SpectraMax® i3x Multi-Mode Microplate Reader
Western blot, imaging, and injectors on one configurable microplate reader.
View ProductsEcho 525 Acoustic Liquid Handler
Rapid acoustic liquid handling design specifically for biochemical and genomic reagent transfer Highly precise and accurate low volume transfers enabling assay miniaturization Suite of Echo Software Applications guide creation of complex protocols
View ProductsBiomek i5 Automated Workstation Liquid Handler
<p>Optimize dependability and walk-away time. The Biomek i5 is a recent addition to our liquid handling portfolio, representing the best of what has made Biomek an industry-leading brand - combined with enhancements suggested by customers around the globe.</p> <ul> <li>Ideal for medium- to high-throughput workflows</li> <li>25 deck positions</li> <li>0.5 µL-1,000 µL (Multichannel) or 0.5 µL-5,000 µL (Span-8) pipetting volume ranges</li> <li>Single Multichannel head (96/384) or Span-8 pipetting with gripper</li> </ul>
View ProductsBiomek i7 Automated Workstation
The most powerful and comprehensive Biomek available. High-throughput 45 deck positions 0.5 - 5,000 µL pipetting volume range Single or dual heads
View ProductsIDBS Polar
An enterprise lab informatics software platform with ELN, LES and LIMS capabilities designed to power scientific innovation.
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