Plasmid DNA (pDNA) Development and Manufacturing

Bioengineering Building Blocks

Plasmid DNA (pDNA) is a key component in the development and manufacturing of biotherapeutics such as mRNA drugs, monoclonal antibodies and gene therapies. These life-saving treatments offer hope to millions of patients worldwide. pDNA is also used for genetic modification within industrial and applied markets for applications such as in vitro-cultivated meat, textiles, polymers and plastics, and flavors.

Plasmids are small pieces of DNA that are separate from the chromosomal DNA found in cells. They are commonly found in bacteria and can replicate independently of the host cell's DNA. Scientists have harnessed the potential of plasmids for engineering by using them as vectors to introduce foreign DNA into cells for research and manufacturing purposes. In bioengineering, high-quality plasmid vectors are essential building blocks for creating biotherapeutics.

pDNA Important Considerations

When designing pDNA libraries from oligonucleotide fragments, it is essential to conduct comprehensive testing to ensure the process and product are of the highest quality and efficiency. This process is crucial as it ensures that the pDNA produced is safe, reliable and effective for the intended purpose. Therefore, it is vital to dedicate sufficient time and resources to testing and screening before scaling up operations to ensure the successful and efficient production of pDNA.

A Range of Solutions, Technologies and Services

The Life Sciences Companies of Danaher support pDNA development and manufacturing with a comprehensive platform of best-in-class science and technology companies. We recognize the necessity for solutions and aim to address these with our extensive instrument, software, and services portfolio. If you want to learn more, please consult with our team of workflow experts.

Plasmid DNA Solutions

To learn more about Plasmid DNA solutions from the Life Sciences Companies of Danaher visit: