CRISPR-Mediated Gene Therapy- One lab, three paths to faster outcomes
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LABORATORY AUTOMATION | DIGITAL SOLUTIONS | ANALYTICAL TOOLS
Preliminary Screening
Select the target, develop the proper gene editing strategy, and screen libraries to select the gRNA.
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LABORATORY AUTOMATION | DIGITAL SOLUTIONS | ANALYTICAL TOOLS
Isolate & Enrich
Obtain patient samples to isolate and enrich the desired cell population.
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LABORATORY AUTOMATION | DIGITAL SOLUTIONS | ANALYTICAL TOOLS
Gene Modification and Analysis
Edit the target gene via a CRISPR-Cas approach and analyze for expected effect.
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ANALYTICAL TOOLS | DIGITAL SOLUTIONS
Expansion
Expand CRISPR-edited cells for downstream characterization.
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LABORATORY AUTOMATION | ANALYTICAL TOOLS | DIGITAL SOLUTIONS
Characterization and Optimization
Characterize molecular consequences of CRISPR edits and optimize as needed.
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ANALYTICAL TOOLS | DIGITAL SOLUTIONS
Functional Assessment
In vitro and in vivo functional activity assessment is performed to inform on risk.
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LABORATORY AUTOMATION | DIGITAL SOLUTIONS
Off-Target Analysis
Chromosomal, sequencing and in silico analyses help uncover and understand off-target effects.
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DIGITAL SOLUTIONS
Regulatory Interaction
Prepare data and reports for regulatory filings in support of the CRISPR-mediated gene therapy.