Oligonucleotide Synthesis

The first step to oligonucleotide synthesis is determining which approach will allow for scaling your process. Outsourcing oligonucleotide synthesis to service providers like IDT can provide increased quality and scale throughout the development and manufacturing process. Bringing nucleotide synthesis in-house can provide more control over workflows and flexibility with sequence modifications. However, the synthesis of oligonucleotides requires controlled conditions and presents a potential environmental hazard because of the amounts of organic solvents required.