One lab, three paths to faster outcomes
LABORATORY AUTOMATION | ANALYTICAL TOOLS | DIGITAL SOLUTIONS
Raw material QC
Oligonucleotide synthesis requires stringent raw material quality control throughout development and cGMP scale-up.
DIGITAL SOLUTIONS
Sequence Design
Design sequences in silico using predictive software, taking care to minimize self-annealing or off-target effects.
DIGITAL SOLUTIONS
Oligo Synthesis
Determine your approach: insourcing, outsourcing or a hybrid. Insourcing oligonucleotide synthesis will require scalability in your process, while vendor selection is key for outsourcing.
LABORATORY AUTOMATION | ANALYTICAL TOOLS | DIGITAL SOLUTIONS
QC and Characterization
Analyze products for the most desirable qualities, such as structure, purity and atomic mass.
LABORATORY AUTOMATION | ANALYTICAL TOOLS | DIGITAL SOLUTIONS
Activity Testing
Develop assays with bioindicator cell lines to assess oligonucleotide binding efficacy and activity. Select the best candidates to move forward with.
ANALYTICAL TOOLS | DIGITAL SOLUTIONS
Purification/Filtration
Purify oligonucleotides from synthesis solutions and chaperones without compromising product quality or integrity.
LABORATORY AUTOMATION | ANALYTICAL TOOLS | DIGITAL SOLUTIONS
Formulation
Create stable formulations of ASOs for further analysis using a combination of in vivo and in vitro testing. Use validated analytical methods to create an effective drug product.
LABORATORY AUTOMATION | ANALYTICAL TOOLS | DIGITAL SOLUTIONS
Tech Transfer to GMP
Scale methods established in development to production volumes or outsource to enterprise operations using cGMP-grade raw materials and reagents.
