Formulation and Bulk Fill
Perform in-depth analysis with a SCIEX ZenoTOF 7600 mass spectrometer and data analysis with Genedata Expressionist Software. Purified mRNA is stabilized in buffers for storage and shipping, concentrated and filtered to remove impurities.
mRNA solutions are separated into smaller volumes and frozen in anticipation of transfer to an analytical laboratory and downstream chemistry, manufacturing and control laboratories. Developing freeze/thaw processes that preserve nanoparticles intact is important for scaling to production.
Genedata Bioprocess increases the efficiency of the end-to-end mRNA development workflow, covering all plasmid production steps (fermentation, harvest, prep, linearization, and filtration), in vitro transcription, and necessary purification and modification operations. It includes formulation screening to identify optimal delivery systems, including lipid nanoparticle (LNP) composition tracking. It facilitates workflow automation, barcoding, and high-throughput processes, capturing all data in a structured format providing a robust data foundation for predictive modeling and AI/ML.