High-Throughput Screening: Enabling Swift Compound Analysis, Accelerating Drug Discovery

Small molecule screening plays a pivotal role during the early stages of drug development. With hundreds of thousands of candidate molecules to choose from, manufacturers must narrow down the funnel quickly to identify potential candidates for further screening. As the screening processes delve deeper into pharmacokinetic profiling, obtaining data and readouts from assays becomes progressively more complex and time-consuming.

For nuanced decision-making, a high-throughput approach is needed to obtain ADME (absorption, distribution, metabolism, and excretion) data pertaining to the metabolic and safety profile of drug compounds. Conventional LC/MS-MS workflows for purifying and screening compounds alone may struggle to meet throughput needs, given the sample preparation and analysis time involved. The challenge in accelerating turnaround is further exacerbated by the sheer volume of drug candidates in the pipeline that need to undergo further screening.

The need is to identify tools to help with method optimization and batch curation for analysis. High-throughput automation solutions by SCIEX, such as the integrated Echo MS system and the LeadScape Analyze software, provide rapid, quantitative, and reproducible MS results at faster turnaround times, when compared to traditional LC-MS/MS analysis. This high-throughput ADME (HT-ADME) workflow thus lets researchers focus on more important tasks at hand.

Integrating the Echo MS compatible SCIEX into this workflow allows easy generation of sample batches and their submission to the SCIEX OS software, speeding up data acquisition and processing. Turnaround time is reduced by over 14X compared to conventional LC-MS/MS systems.

Embracing the power of precision to automate method creation, batch curation, and result generation, the HT-ADME solutions by SCIEX empower researchers to make small molecule drug discovery more efficient and high-throughput.Contact an expert at the Life Sciences companies of Danaher Corporation to learn how you can integrate these tools into your workflow.