Antibody Characterization for Cell Line Development
Measuring product and critical quality attributes is an important analytical strategy for the characterization of monoclonal antibodies (mAbs). Having a robust antibody quality control process in place requires understanding and selecting the proper attributes to measure.
Antibody isotyping, concentration, structure, charge heterogeneity, post-translational modifications (PTMs), activity and stability are common targets for analysis. This requires implementing robust solutions across multiple analytical and sample preparation technologies, such as mass spectrometry, capillary electrophoresis, high-performance liquid chromatography (HPLC), automated liquid handling and data management.
The Life Sciences companies of Danaher offer all these and more. Below are a few innovative technologies that ensure a robust and reproducible antibody characterization and antibody quality control process.
- SCIEX Biophase 8800 system expedites mAb purity analysis and can be used to study consistency over time.
- SCIEX ExionLC AE system and SCIEX ZenoTOF 7600 system provide an integrated and intuitive platform for mass analysis .
- SCIEX Intabio ZT system provides multidimensional analysis, such as intact protein analysis, charge variant analysis and PTM characterization.
- Phenomenex Biozen Biologics LC Columns are used for analytical separations and analyzing product attributes.
- Automate your sample prep with a Beckman Coulter Life Sciences Biomek i-Series Automated Workstation.
- Capture and manage your data with the IDBS Polar BioPharma Lifecycle Management platform.
- Streamline mass spectrometry data analysis with Genedata Expressionist Software.
Antibody Characterization Products
ZenoTOF 7600 System for Mass Spectrometry
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
View ProductsBiomek i5 Automated Workstation Liquid Handler
<p>Optimize dependability and walk-away time. The Biomek i5 is a recent addition to our liquid handling portfolio, representing the best of what has made Biomek an industry-leading brand - combined with enhancements suggested by customers around the globe.</p> <ul> <li>Ideal for medium- to high-throughput workflows</li> <li>25 deck positions</li> <li>0.5 µL-1,000 µL (Multichannel) or 0.5 µL-5,000 µL (Span-8) pipetting volume ranges</li> <li>Single Multichannel head (96/384) or Span-8 pipetting with gripper</li> </ul>
View ProductsBiomek i7 Automated Workstation
The most powerful and comprehensive Biomek available. High-throughput 45 deck positions 0.5 - 5,000 µL pipetting volume range Single or dual heads
View ProductsBiozen LC Columns
From mAbs to Oligos, We Have You Covered Phenomenex is committed to the development of novel chromatographic solutions that advance biopharmaceutical development. This rapidly-growing industry necessitates fit for purpose applications and innovative technologies to meet the expanding analytical challenges of the field. Phenomenex columns and sample preparation solutions are designed to tackle the multi-faceted analytical needs of large molecule analysis, particularly in the area of biopharmaceutical analysis. Leveraging cutting-edge technology and expertise, our biopharmaceutical solutions provide tailored support for accurate and reliable results in this specialized field.
View ProductsGenedata Biopharma Platform: Biopharma Automation & AI
Genedata transforms biopharma R&D through automation, advanced analytics, and AI. As the first biologics-native technology company, we lead digitalization and enable data-driven decision-making for biopharma organizations worldwide. The Genedata Biopharma Platform combines a unified data model with workflow automation and embedded AI to accelerate and optimize end-to-end discovery and development of biologics and other modalities.
View ProductsExionLC™ 2.0 and ExionLC™ 2.0+ Systems
Reproducibility, reliability and carryover performance that meets your workflow demands, injection to injection, batch after batch. ExionLC 2.0 and ExionLC 2.0+ systems provide full integration, control and compatibility with SCIEX mass spectrometers bringing together the speed and precision you expect for a complete solution that meets every challenge your lab faces.
View ProductsIntabio ZT System
Comprehensive charge variant analysis made simple The Intabio ZT system couples icIEF separation and UV detection with high resolution mass spectrometry on the ZenoTOF 7600 system.
View ProductsIDBS Polar
An enterprise lab informatics software platform with ELN, LES and LIMS capabilities designed to power scientific innovation.
View ProductsBioPhase™ 8800 system
The BioPhase 8800 capillary electrophoresis system is a multi-capillary instrument designed for efficiency and ease-of-use operation for the analysis of purity and heterogeneity of biotherapeutics and the characterization of protein, peptides, nucleic acids and other molecular species.
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