BioPhase™ 8800 system
The BioPhase 8800 capillary electrophoresis system is a multi-capillary instrument designed for efficiency and ease-of-use operation for the analysis of purity and heterogeneity of biotherapeutics and the characterization of protein, peptides, nucleic acids and other molecular species.
Same foundation. More muscle.
The BioPhase 8800 system is a multi-capillary electrophoresis system that enables biopharma scientists to run multiple samples in parallel, accelerating the development and execution of sensitive, high-throughput analytical methods.
Take charge of the development pipeline, assess molecular liabilities more quickly, and enable rapid developability assessments to streamline the selection of candidates for progression into an effective therapy.
The BioPhase 8800 system is designed to advance your workflows into the next phase of biopharmaceutical development. With streamlined migration, consistent performance, and proven reliability, it’s the evolution that feels like home.
One platform, multiple ways to make it yours.
Gain valuable insights into quality attributes of biotherapeutics with kit-based assays and customizable features to address the evolving drug development pipeline. Ensure consistent, reproducible results with liquid temperature control, multiple injection modes, and simple switching between native fluorescence (NF), UV, or laser-induced fluorescence (LIF) detection modes.
Parallel processing
Get to the answer sooner with a boost in throughput
- Parallel processing with 8 capillaries to speed up method development
- Equal separation voltage applied to each capillary for high reproducibility
- Factory-built cartridges and push-in loading reduce user error
Multiple detectors
Flexibility for your workflow requirements
- UV detection to enable bridging to legacy data
- NF detection for simplified peak identification, quantitation, and enhanced sensitivity.
- LIF detection for high-sensitivity detection of dye-labeled protein and oligos
Temperature control
Achieve consistent outcomes with precise temperature control
- Liquid-based temperature control of each capillary to maximize data reproducibility
- Uniform temperature control across the sample plate to maintain sample stability
- Rapid heating and cooling of sample chamber from 4-37°C to be ready for what’s next
Injection mode
Stay flexible with precise injection control
- High-precision, low-pressure injection mode to ensure uniform sample introduction
- Consistent pressure delivery for whole capillary filling
- Electrokinetic injection to maintain resolution
Software
Quick and easy results with intuitive, large touchscreen interface
- Drag and drop method programming to create methods with ease
- Remote method and data analysis software at your desk
- Compatibility with Empower chromatography data system for data integrity.
Kit-based workflows
Maximize productivity with kitted reagents and methods
- Support core analytical workflows
- Minimize method development
- Adapt to new modalities with ease
Multiple detector types
Integrated optical detection on the BioPhase 8800 system eliminates the need for manual detector changes, enabling seamless switching between detection modules. Choose NF, UV, or LIF depending on workflow needs.
Native fluorescence detection
Gain faster and more confident peak integration with significantly increased signal-to-noise ratio and a stable baseline.
NF detection offers increased sensitivity compared to traditional UV detection for CE-SDS, cIEF, and CZE assays. Eliminate the need for protein-fluorescence-dye conjugation during sample preparation.
Establish CE methods that meet today’s complexity and tomorrow’s pressure.
With kit-based CE workflows from SCIEX, your lab stays ready for what’s next, no rebuild required. Whether it’s a new modality, a shift in format, or an urgent timeline, respond without overhauling your system.
Protein-based therapeutics
- CE-SDS – Determine the apparent molecular weight of proteins to evaluate the size heterogeneity, purity, and manufacturing consistency of biologics
- CZE – Accelerate charge heterogeneity analysis with native capillary zone electrophoresis
- cIEF – Establish the identity and stability of the molecule with accurate determination of a protein’s charge heterogeneity
- Fast glycan identification – Combine simplified sample preparation, rapid separations, and automated glycan identification to make confident decisions quickly
In vitro transcribed RNA
- mRNA purity and integrity – RNA integrity and quality analysis is critical to ensuring the efficacy of RNA-based therapeutics and vaccines. Discover kit-based solutions designed for the separation of single-stranded oligonucleotides from 50-9,000 nucleotides and beyond
- Purity of plasmid starting material – Assess linear DNA sizes and purity confidently with ultra-high resolution over a wide size range
Viral vectors
- Capsid protein purity – Avoid lengthy assay adjustments with a kit-based protein profiling workflow suitable across serotypes and viral vectors
- Virus genome integrity – Confidently determine genome integrity, genome titer, and impurities
- Empty full capsid ratio – Determine multiple CQAs, including full-and-empty ratios, on one platform
- Purity of plasmids - Determine the purity of supercoiled critical starting material across a wide size range
- Host cell nucleic acids – Assess residual nucleic acid sizes and quantities simultaneously
Gene editing
- Purity and integrity of sgRNA and mRNA – Understand related nucleic acid impurities and determine sizes and quantities over a wide size range (50 to 9,000 nt)
- Purity of plasmid starting material – Assess linear DNA sizes and purity confidently with ultra-high resolution over a wide size range