Monoclonal Antibody (mAb) Development, Manufacturing & Production Solutions

The Importance of Therapeutic Antibodies

Therapeutic antibodies are complex biologics with critical applications in treating many diseases, such as cancer, autoimmune disorders and infectious diseases.  Monoclonal antibodies (mAbs) are proteins produced by immune cells (specifically B-cells) but can also be secreted from engineered mammalian cells after the cell line development process.

Engineered antibodies resemble natural human antibodies with heavy and light chains and perform similar functions, such as tagging cancer cells for antibody-mediated targeting to alert immune cells, leading to cell death. However, a lack of antibody specificity and the complex nature of tumor microenvironments can interfere with antibody efficacy and limit applications for some engineered mAbs. Therefore, therapeutic antibodies must be designed with specific targets and mechanisms of action in mind.

For example, polyspecific monoclonal antibodies, such as bispecific antibodies and trispecific antibodies, are genetically engineered to simultaneously engage multiple epitopes. This novel class of antibodies, in addition to antibody fragments and antibody-drug conjugates (ADCs), is a focus of solid tumor therapeutics with the goal of eradicating tumor cells more precisely and effectively. Due to their complex structures, bi- and trispecific antibodies can experience a challenging development and manufacturing process.

A Range of Solutions, Technologies and Services

The Life Sciences companies of Danaher provide a wide range of solutions and fit-for-purpose technologies to help streamline these processes, enabling the efficient generation of high-quality therapeutic antibodies.

Monoclonal Antibody Solutions

To learn more about monoclonal antibody solutions from the Life Sciences companies of Danaher, visit: