Autologous CAR-T Cell Therapy Workflow Process Steps | Danaher Life Sciences

Autologous CAR-T Cell Therapy - One lab, three paths to faster outcomes

All

Leverage the extensive portfolios of our Life Sciences companies and accelerate Preclinical and Clinical Development for Autologous CAR-T Cell Therapies.

Laboratory Automation

Increase workflow reproducibility and standardization with cutting-edge tools.

Analytical Tools

Gain critical insights faster with scalable solutions.

Digital Solutions

Enterprise-level workflow management, data handling and analyses.

1

LABORATORY AUTOMATION | DIGITAL SOLUTIONS | ANALYTICAL TOOLS

Cell Separation

Isolate patient-derived T cells from a clinical sample.

2

LABORATORY AUTOMATION | DIGITAL SOLUTIONS | ANALYTICAL TOOLS

Activation

Activate isolated CD3⁺ T cells with stimulatory ligands.

3

LABORATORY AUTOMATION | DIGITAL SOLUTIONS | ANALYTICAL TOOLS

Gene Modification and Analysis

Modify activated T cells with selected CAR construct and vector, then analyze.

4

LABORATORY AUTOMATION | DIGITAL SOLUTIONS | ANALYTICAL TOOLS

Cell Expansion

Expand newly modified CAR-T cells.

5

LABORATORY AUTOMATION | DIGITAL SOLUTIONS | ANALYTICAL TOOLS

Harvest, Fill & Finish

Wash and concentrate harvested CAR-T final cell populations for formulation and fill-finish steps.

6

LABORATORY AUTOMATION | DIGITAL SOLUTIONS | ANALYTICAL TOOLS

Release Testing

Perform final product QC and release testing to document identity, potency, purity, dosage and safety.