Cell Separation

Cell Separation and Isolation Technologies for Autologous CAR-T Cell Therapy

T cells or PBMCs must be harvested from patient samples for downstream processing. The Beckman Coulter Life Sciences Avanti JXN-26 Series High-Performance Centrifuges can help separate and concentrate cells after collection and are available with enhanced data management, which can support GMP processes. Cell viability can be assessed using a Beckman Coulter Life Sciences Vi-CELL BLU Cell Viability Analyzer.

Phenotypic assays requiring microplate imaging readouts can be performed using a Molecular Devices SpectraMax Multi-mode Reader with Softmax Pro GxP software. Sample preparation can be performed on a Beckman Coulter Life Sciences Biomek i-Series Automated Workstation that supports 21 CFR Part 11. Collect and track experiment and instrument data within discovery or development labs with the IDBS Polar Biopharma Lifecycle Management software.

To enhance GMP manufacturing, the IDBS Skyland PIMS platform can be used for a 21 CFR Part 11 compliant digital backbone and end-to-end analytics workspace. By doing so, it is possible to seamlessly combine product and process data, resulting in reduced production costs, fewer batch failures and easier regulatory reporting. In GMP-compliant environments, monitoring can be performed with a Beckman Coulter Life Sciences MET ONE 3400+ Series Portable Airborne Particle Counter and Beckman Coulter Life Sciences PAT700 Total Organic Carbon Analyzer.

To unify and streamline these diverse processes, the Genedata Biopharma Platform serves as a central hub for data capture, analysis and management. It tracks sample metadata, environmental monitoring data, viability and phenotype measurements. It also supports GMP-compliant data processing, analysis and reporting.