Modern drug development relies on producing high-quality, actionable data at every stage. As therapeutic modalities become more complex, analytical technologies are crucial for understanding molecular behavior, ensuring product quality and meeting evolving regulations requirements.

Mass spectrometry (MS) is an analytical technique used for the identification and quantification of molecules based on their mass-to-charge ratio (m/z). This technology delivers high-resolution molecular insights for small molecule and large biomolecule analysis.

MS addresses the evolving therapeutic landscape with:

SCIEX ZenoTOF 8600 System

The ZenoTOF 8600 system is a high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity and high-energy EAD fragmentation technology. Coupled with the comprehensive and high-throughput Zeno SWATH DIA 2.0, it offers high-speed, broad molecule support with enhanced selectivity for improved quantitative accuracy and identification.

This innovative solution provides an integrated and intuitive platform for mass analysis, including:

• Characterize large molecules, including post-translational modifications
• Elucidate positional isomers on complex therapeutics
• Identify and quantify proteins and peptides with confidence
• Gain significant sensitivity and discover low-abundance biomolecules.

We see a way to fully characterize intact proteins 95% faster*

SCIEX | Intabio ZT system

*vs. traditional fraction collection and LC-MS analysis approach

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SCIEX Intabio ZT System

The Intabio ZT system is the first fully integrated platform to combine imaged capillary isoelectric focusing (icIEF) separation, UV detection and peak identification with mass spectrometry (MS).

By leveraging the connectivity between icIEF and MS assays, the Intabio ZT system enables rapid separation, quantitation and identification of biotherapeutics at the intact protein level. Enabling faster and more confident charge variant identification.

The Intabio ZT system empowers researchers to overcome challenges in early drug development and streamline the selection of promising drug candidates.

As new therapies develop, analytical needs will keep changing. Our technologies are built to handle current challenges and grow with future pipelines. Contact an expert today to see how we can work together to meet your analytical needs.