Cell Line Selection for Cell Line Development
Single cell lines are expanded across generations to screen for high productivity and stability. However, stability studies are laborious and required by regulatory bodies to assess clone characteristics such as mAb titer measurements and robustness. Select winners with desired titers using theBeckman Coulter Life Sciences ValitaTiter IgG Quantification assay. This assay can be fully automated using a Beckman Coulter Life Sciences Biomek i-Series Automated Workstation and Molecular Devices SpectraMax microplate reader. Cell viability can be assessed with the Beckman Coulter Life Sciences Vi-CELL BLU Cell Viability Analyzer. The Beckman Coulter Life Sciences Cydem VT Automated Clone Screening System can reduce the amount of manual work required during clone screening by integrating a liquid handler, bioreactor, cell counting, viability and titer in a single purpose-built platform. Packaging these solutions with theIDBS Polar Biopharma Lifecycle Management platform to capture and curate data will ease regulatory compliance and tech transfer.
Genedata Bioprocess increases the efficiency of the end-to-end cell line development workflow, encompassing plate management, pool and cell line tracking, data aggregation from instruments, selection decision-making, cell bank inventory and cell line history reporting. It facilitates workflow automation, barcoding, and high-throughput processes, capturing all data in a structured format to create a robust data foundation for predictive modeling and AI/ML.