Our integrated digitizer is capable of eliminating 50/60 Hz line-frequency interference on up to four channels in parallel. The function is activated with a simple software checkbox. The low-noise data acquisition software supports eight analog input channels and offers four acquisition modes, allowing simultaneous digitization of all eight channels at a rapid sampling rate of 500 kHz per channel, which means you can record cellular networks without 50/60 Hz line-frequency noise in a single digitizer, saving time and reducing costs. This makes it suitable for single-channel and multi-channel electrophysiology data acquisition and analysis. Furthermore, the digitizer employs digital outputs to control external devices like stimulus isolators or LED lights. Each digital output channel sends a 5V TTL signal, with the software allowing for precise control of these outputs. Our dedicated teams are readily available to assist customers through remote or on-site product demonstrations and webinars, providing valuable support to address their challenging research needs.
Features
Essential features of our Patch-clamp Digitizers
- Our low-noise digitizer is a sophisticated feature that intelligently identifies and eliminates local 50/60 Hz line-frequency noise patterns and their associated high-frequency harmonics within incoming signals, accommodating up to 20 V peak-to-peak.
- It can digitize a broad range of input signals, spanning from -10 to +10 V.
- The software suite is the predominant program for acquiring and analyzing patch-clamp electrophysiology data, widely utilized for controlling and recording experiments in voltage-clamp, current-clamp, and low-noise patch-clamp configurations.
- The software can automatically detect variations in noise amplitudes and swiftly remove noise without affecting the acquired signals.
- The noise-canceling system does not function as a filter and does not introduce signal distortions like changes in frequency, amplitude reduction, phase shifts, or alterations in DC voltage levels.
- The anti-noise system swiftly identifies fluctuations in noise amplitudes and adjusts by eliminating the noise in under one second.
Applications
Applications of Patch-clamp Digitizer
- Low-noise patch-clamp digitizer is invaluable tool for precisely monitoring and quantifying the changes in membrane potential and ion channel behavior in response to various stimuli, helping researchers gain comprehensive insights into the role of ion channels in essential biological processes, including cell differentiation, migration, disease mechanisms, and neuronal signaling, which is vital for both fundamental research and drug development.
- Our high-resolution low-noise digitizer plays a pivotal role in converting analog signals acquired by amplifiers in patch-clamp experiments into digital data, enabling high-resolution analysis. In particular, the latest digitizer, with a sampling rate of 500 kHz and noise silencing capabilities, is essential for recording precise electrophysiological data, free from 50/60 Hz line-frequency noise, making it invaluable in neuroscience research for studying the intricate dynamics of neural activity and synaptic transmission.
- Our Digitizer plays a crucial role in analyzing complex electrical signals from ion channels in diseases like hypertension, cardiac arrhythmias, and cancer. They aid researchers in understanding ion channel behavior, leading to potential strategies for disease modulation and innovative therapies.
- The instrument is vital for advancing drug development, allowing precise monitoring and analysis of complex cellular responses. It excels in capturing electrical signals from advanced 3D cell culture models, improving predictions of drug potential, shortening development timelines, and boosting pharmaceutical industry efficiency.
- Our Digitizer play a vital role in planar lipid bilayer electrochemistry by enabling the precise capture and analysis of electrical signals during membrane interactions, ensuring accurate monitoring of ion channel behavior and membrane properties.
FAQs
In whole-cell patch-clamp experiments, how do digitizers enable researchers to effectively record the electrical activity of multiple cells?
In whole cell patch-clamp experiments, digitizers play a crucial role in enabling researchers to record the electrical activity of multiple cells simultaneously. They achieve this by providing the capability to capture and digitize the electrical signals from various cells in real time. By supporting multiple input channels and offering high-speed data acquisition, digitizers ensure that the electrical activity of each cell is accurately and independently recorded, facilitating comprehensive studies of cellular responses, ion channel behavior, and other critical electrophysiological parameters across multiple cells in parallel.
Why should I choose these digitizers for my research?
These digitizers, featuring innovative noise-canceling technology, offer exceptional capabilities as some of the most advanced analog-to-digital signal converters available. This advanced feature not only removes 50/60 Hz line-frequency noise but also effectively eliminates high-frequency harmonics from incoming signals, ensuring the utmost signal purity. Our digitizers work seamlessly with cutting-edge software that supports eight channels of analog acquisition and provides four acquisition modes for versatile data acquisition and analysis. With the capability to eliminate line-frequency noise on up to four channels simultaneously, these digitizers are an excellent choice for high-resolution trace recording and digitizing cellular network studies. They not only ensure data accuracy but also save time and resources. They are valuable assets for your research endeavors. The digitizers, along with the patch clamp amplifiers, provide exceptionally low-noise single-channel recordings using actively cooled head stages with capacitor-feedback technology, and the state-of-the-art software enhances the efficiency and precision of your research.
How does the digitizer with low noise data acquisition system effectively address the issue of 50/60 Hz line-frequency noise, also known as electrical hum, in patch-clamp electrophysiology experiments?
The digitizer with low noise data acquisition system effectively addresses the issue of 50/60 Hz line-frequency noise, or electrical hum, in patch-clamp electrophysiology experiments through its adaptive and filter-free technology. It quickly learns and removes local line-frequency noise patterns from incoming signals in less than one second, ensuring that background noise is efficiently eliminated. This results in a clean and accurate signal, making sensitive current or voltage measurements feasible and significantly enhancing the quality of data obtained in patch-clamp experiments.