UC Enuity Ultramicrotome

UC Enuity allows you to monitor the fluorescence signal during sectioning at both room temperature and in cryo conditions.

Quickly identify your region of interest in the resin block.

Rely on UC Enuity to reach the buried target with 3D µCT data-based target trimming.

• Load 3D µCT data to define and target a specific plane of interest within a resin block.
• Precisely and accurately trim the sample block, removing excess of resin
• Expose the plane of interest and get ready for sectioning

See how it works: https://www.youtube.com/watch?v=RKNbG1UFDhc

Speed up your volume EM research with UC Enuity. Prepare uniform, ultra-thin and thin ribbons for your array tomography experiments, at reduced risk of losing precious sections.

You can collect uniformly aligned ultra-thin sections straight on the wafer, for fast and reliable transfer into the electron microscope.

Elevate your research journey with an easily upgradable ultramicrotome, empowering you to expand capabilities and maximize the scientific potential of your experiments.

Upgrade your ultramicrotome with additional modules

Start with the basic UC Enuity instrument and seamlessly upgrade with add-on modules to a fully featured system equipped for your specific needs.

With UC Enuity’s precise temperature control and an integrated cryo chamber including micromanipulators and cryosphere, ice contamination is minimized. During sample manipulation, micromanipulators and the EM CRION offer stability and flexibility.

Your benefits

• Rely on UC Enuity's precise temperature control to maintain optimal cooling conditions for every sample, even in humid conditions.
• Ensure reliable and precise sample collection, minimizing the risk of section loss or displacement.
• Expand your UC Enuity with the cryochamber to a state-of-the-art cryo sectioning system in just a few minutes.

UC Enuity prioritizes your comfort by offering adaptable ergonomics for users. You will be able to sit comfortably at UC Enuity, even for time-consuming cryosectioning tasks.

How UC Enuity adapts to you

• Easily adapt the system's geometry to accommodate your ergonomic needs.
• Adapt the height and angle of the stereo microscope to align with your height and position.

Rest your arms comfortably on cushioned supports for a more ergonomic and user-friendly experience.

Safety comes first with UC Enuity. You can access fluorescence information safely with UV-blocking shields for both room temperature and cryo setups.

With UC Enuity’s enclosed design you will have confidence in safe liquid nitrogen handling that prevents the user from direct exposure.

Now you can enhance your system's performance with RemoteCare from Leica Microsystems to keep your system running smoothly. Anomalies are detected proactively with UC Enuity, receiving instant notifications for 20+ error codes.

You can also access 30+ critical parameters in real-time for swift issue resolution. Ensure constant monitoring for proactive system maintenance, maximizing your UC Enuity's uptime and streamlining troubleshooting.

I had the opportunity to use the new UC Enuity, and I was particularly impressed by the motorized knife block and segment arc. These features enable precise adjustment of small angles and allow for accurate rotation of the sample by setting a defined degree. Another notable feature is the Auto-Trim function, which is especially helpful for beginners who may struggle with aligning the sample to the knife. While experienced users might align the sample faster manually, the Auto-Trim function can still save time, allowing them to focus on other tasks. The new UC Enuity will simplify the cutting process.

Dr. Vanessa Zheden, Institute of Science and Technology Austria (ISTA)