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UC Enuity Ultramicrotome

Leica Microsystems Uc Enuity Hero

Experience the cutting edge of automation and precision

Do you need to produce thin or ultra-thin sections for EM sample preparation?

Introducing UC Enuity, the next generation ultramicrotome that saves you valuable time and resources through its automated setup functions, providing state-of-the-art sectioning quality.

UC Enuity Cryo

UC Enuity Cryo

Next generation Ultramicrotome for the preparation of semi- and ultra-thin sections, as well as smooth surfaces required for LM, TEM, SEM, and AFM examination. Fully upgradable ultramicrotome to grow with your needs. Includes remote care. Cryo Chamber is compatible for connection to the EM VCT500, Cryo CLEM and Cryo TEM systems. Double Cryo Micromanipulator for cryogenic sectioning of Tokuyasu and CEMOVIS specimen samples is compatible with UC Enuity Cryo Chamber.

UC Enuity Advance Room Temperature

UC Enuity Advance Room Temperature

Next generation Ultramicrotome for the preparation of semi- and ultra-thin sections, as well as smooth surfaces required for LM, TEM, SEM, and AFM examination. State of the art motorized segment arc and knife block and enabled automated setup functions. Intuitive and configurable user interface. Fully upgradable ultramicrotome to grow with your needs. Includes remote care.

Work smarter with automated technology

Experience the future of ultramicrotomy with autoalignment of block face and knife, and auto trimming.

Make every section count

Trim towards your target with the help of fluorescence or µCT data and deliver high quality sections for volume electron microscopy experiments.

Achieve consistent cryosectioning

Experience better quality cryo sections with superb precision and safety.

Empower your team through automation

Reduce the need for user training thanks to autoalignment - an auto approach mode which brings block face and knife together, automatically.

UC Enuity handles the trimming for you - all you need to do is define the boundaries of your sample block, and walk away.

Trim your target with the help of fluorescence

UC Enuity allows you to monitor the fluorescence signal during sectioning at both room temperature and in cryo conditions.

Quickly identify your region of interest in the resin block.

Make every section count for volume EM experiments

Speed up your volume EM research with UC Enuity. Prepare uniform, ultra-thin and thin ribbons for your array tomography experiments, at reduced risk of losing precious sections.

You can collect uniformly aligned ultra-thin sections straight on the wafer, for fast and reliable transfer into the electron microscope.

Three consecutive ribbons for Array Tomography, 30 sections each, 70 nm feed. The ribbons were prepared with UC Enuity Volume EM module. After automatically cutting the ribbons, UC Enuity added two release cuts of 100 nm thickness at the end of each ribbon.

Three consecutive ribbons for Array Tomography, 30 sections each, 70 nm feed. The ribbons were prepared with UC Enuity Volume EM module. After automatically cutting the ribbons, UC Enuity added two release cuts of 100 nm thickness at the end of each ribbon.

Unlock the full potential of ultramicrotomy

Elevate your research journey with an easily upgradable ultramicrotome, empowering you to expand capabilities and maximize the scientific potential of your experiments.

Upgrade your ultramicrotome with additional modules

Start with the basic UC Enuity instrument and seamlessly upgrade with add-on modules to a fully featured system equipped for your specific needs.

Easily upgradable ultramicrotome, empowering you to expand capabilities and maximize the scientific potential of your experiments.

Reduce contamination and increase section quality

With UC Enuity’s precise temperature control and an integrated cryo chamber including micromanipulators and cryosphere, ice contamination is minimized. During sample manipulation, micromanipulators and the EM CRION offer stability and flexibility.

Your benefits
  • Rely on UC Enuity's precise temperature control to maintain optimal cooling conditions for every sample, even in humid conditions.
  • Ensure reliable and precise sample collection, minimizing the risk of section loss or displacement.
  • Expand your UC Enuity with the cryochamber to a state-of-the-art cryo sectioning system in just a few minutes.

UC Enuity with cryo chamber for minimized ice contamination.

Reduce fatigue with adaptable ergonomics

UC Enuity prioritizes your comfort by offering adaptable ergonomics for users. You will be able to sit comfortably at UC Enuity, even for time-consuming cryosectioning tasks.

How UC Enuity adapts to you
  • Easily adapt the system's geometry to accommodate your ergonomic needs.
  • Adapt the height and angle of the stereo microscope to align with your height and position.

Rest your arms comfortably on cushioned supports for a more ergonomic and user-friendly experience.

Protect yourself, your samples, and your equipment

Safety comes first with UC Enuity. You can access fluorescence information safely with UV-blocking shields for both room temperature and cryo setups.

With UC Enuity’s enclosed design you will have confidence in safe liquid nitrogen handling that prevents the user from direct exposure.

Maximize uptime with RemoteCare

Now you can enhance your system's performance with RemoteCare from Leica Microsystems to keep your system running smoothly. Anomalies are detected proactively with UC Enuity, receiving instant notifications for 20+ error codes.

You can also access 30+ critical parameters in real-time for swift issue resolution. Ensure constant monitoring for proactive system maintenance, maximizing your UC Enuity's uptime and streamlining troubleshooting.

What section thickness is typical for ultramicrotomy in TEM and SEM array tomography?
Ultramicrotomy produces ultrathin sections commonly used for TEM and SEM-based volume workflows such as array tomography. Typical section thickness is ~50–300 nm for TEM, while SEM array tomography typically requires sections below 50 nm.
How does automated knife-to-block alignment reduce onboarding time for new ultramicrotomy users?
Automated alignment makes critical setup steps easier to teach and repeat across changing users. UC Enuity automatically aligns block face and knife, supported by an integrated camera and large on-screen interface so trainers and trainees can follow actions together. Motorized micro-step adjustments (knife angle, sample tilt, and rotation) support controlled fine alignment, helping users start sectioning with more confidence and consistency.
How can automated trimming help create a parallel-edged block face and improve ribbon formation?
Automated trimming helps standardize block-face preparation for smoother sectioning and easier pickup. With UC Enuity, define boundaries once and use AutoTrim to shape a rectangular or trapezoid block face in a single run, supporting parallel edges that help ribbon formation and reduce hands-on time for standard trimming tasks. A clean block face can also help protect diamond knives before sectioning.
Can I target a fluorescently labeled region of interest while trimming or sectioning (room temperature and cryo)?
Yes. UC Enuity supports fluorescence-guided trimming and sectioning so you can follow fluorescent signals during preparation and reach regions of interest with fewer detours. Fluorescence monitoring is available at room temperature and under cryo conditions when used with the M205 FA stereomicroscope, supporting correlative workflows by helping target labeled regions efficiently for downstream electron microscopy preparation.
How can fluorescence targeting help me for CEMOVIS?
In CEMOVIS, you require a small blockface because of the mechanics and physics of cutting vitrified water, not because of imaging constraints. A large block face increases cutting artefacts and makes high‑quality vitreous sections essentially impossible. Therefore, fluorescence targeting is especially powerful for CEMOVIS because it lets you precisely identify the correct position in your sample.
How does cryo planing improve my correlative workflow?
Cryo planing is controlled surface trimming or polishing at cryogenic temperatures to remove contamination, reduce ice artifacts, and expose regions of interest. It also helps achieve smoother surfaces and improve resolution of fluorescence imaging for better correlation of light and electron microscopy.
How can 3D µCT data be used to trim precisely to a buried plane of interest in resin blocks for volume EM?
Import 3D µCT data, define the plane you want to reach, and use guided trimming to remove excess resin and expose the target plane. UC Enuity supports accurate 3D target trimming based on µCT data, helping reduce trial-and-error when targets are buried in resin. This can help you start downstream 3D volume acquisition closer to where it matters for volume EM workflows.