Our cutting-edge patch clamping systems support a wide spectrum of patch-clamp technology experiments, covering everything from the tiniest single-channel recordings to the most extensive macroscopic observations. Our systems offer comprehensive solutions for patch-clamp electrophysiological workflows and feature the most commonly utilized software in the field. These systems make multi-channel experiments easily achievable, and we deliver signal-to-noise ratios that approach the theoretical limits of physics.
Our patch clamps are versatile instruments used in electrophysiology to study ion channel behavior. Electrophysiology is applied to various cell types, engineered to overexpress single ion channels. These patch clamp solutions aid in understanding ion channel behavior in normal and disease conditions and the effects of various drugs, ions, or analytes on these conditions.
We offer complete solutions for patch-clamping, covering whole-cell patch-clamp, extracellular, and single-channel recordings, which include amplifiers, digitizers, software, and accompanying accessories. We can provide the perfect amplifier choice for your specific application, ensuring the highest quality data acquisition. Our experienced teams work closely with customers, offering remote and on-site product demonstrations, webinars, and other resources to assist in overcoming your research obstacles.
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Patch Clamp Amplifiers
Our series of amplifiers provide best-in-class solutions for the entire range of patch-clamp experiments. The portfolio includes amplifiers specially designed for ultra low-noise single-channel recordings, whole-cell voltage-clamp, high-speed current-clamp recordings, and two-electrode voltage-clamp, current-clamp recordings.
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Patch Clamp Digitizers
Our state-of-the-art patch-clamp digitizer, cutting-edge analog-to-digital signal converter, stands out in the market with it’s groundbreaking line synchronous noise-canceling capability. This instrument is a part of our top-of-the-line patch-clamp product portfolio, which also comprises amplifiers, software, and accessories, providing all-encompassing complete workflow solutions for patch clamp experiments. The digitizer is versatile and applicable for both episodic stimulation and continuous gap-free experimental protocols.
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Patch Clamp Software Suite
Our advanced patch-clamp software for acquiring and analyzing patch-clamp electrophysiology data offers enhanced flexibility and streamlined data acquisition, saving valuable time while enabling more comprehensive discoveries. The electrophysiology software seamlessly integrates both electrophysiological data acquisition and analysis, simplifying the entire workflow.
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Features
Essential features of our Patch Clamp Instruments
- Our patch-clamp system efficiently eliminates 50/60 Hz line-frequency interference on up to four channels simultaneously with a simple software activation.
- The software includes various modules and tools that streamline setup and support parameter automation and features an enhanced protocol editor, allowing for longer and more intricate protocols reducing setup time.
- Our extensive range of amplifiers ensures we can match the perfect solution to your specific application, guaranteeing the highest quality data.
- The gap-free mode permits command and digital outputs to be programmed continuously during recording, enhancing protocol design and enabling automatic actions within the protocol.
- Advanced modules facilitate automatic measurements of action potentials and population spikes.
- The new Batch Analysis feature enables the analysis of multiple datasets using the same macro, saving time and ensuring consistent analysis for each dataset.
Applications
Applications of our Patch-Clamp Systems
- Our patch clamps are used to study the impact of ion channel function in neuronal communication, providing insights into how ion channels influence normal and abnormal neurological processes, which can be valuable for understanding conditions like epilepsy or neurodegenerative diseases.
- They are utilized to investigate the precise generation and propagation of action potentials in neurons, enabling researchers to understand the intricacies of neuronal signaling and study various aspects of neurophysiology, including ion channel function and the effects of drugs or genetic mutations on neuronal excitability.
- Our patch clamp solutions help study the behavior of single ion channels in a cell membrane, offering detailed insights into ion channel kinetics and conductance. These are critical for understanding ion channelopathies, drug interactions, and the functioning of various ion channels in neurons and other excitable cells.
- The whole cell configuration is crucial in studying cardiac myocytes to assess and manipulate the transmembrane voltage, thereby enabling detailed investigations of ion channel currents and cardiac electrophysiology, which is vital for understanding arrhythmias, drug effects, and cardiac disorders.
- The patch clamp technique is extensively employed by researchers worldwide to explore various aspects of neurobiology and cellular physiology, including the investigation of how amyloid beta peptides affect ion channels in Alzheimer's disease, the evaluation of signaling mechanisms involved in memory and recall processes in the brain, and the study of the molecular mechanisms of inhibitory synapses.
What are the essential components and steps involved in a patch-clamp experiment using the whole-cell patch configuration?
In a whole-cell patch-clamp experiment, the critical components include a patch pipette filled with pipette solution, which forms a tight seal on the cell membrane, and the patch configuration is established. The patch pipette is connected to a patch-clamp rig and an amplifier to record intracellular signals. Suction is applied to gently rupture the patch of the membrane, providing access to the cell's interior and allowing researchers to investigate ion channel behavior and cellular electrophysiology.
How does the system achieve high signal-to-noise ratios?
The patch clamp system achieves high signal-to-noise ratios by forming a giga-ohm seal, using low-noise amplification, optimizing electrode design, employing sophisticated signal processing, and maintaining a stable environment to minimize noise interference in the recorded signals.
What is the perforated patch clamp technique used for?
The perforated patch clamp technique is primarily used to record and study the electrical activity of cells while preserving their natural intracellular environment, making it valuable for researching ion channel physiology and cellular responses under near-physiological conditions.
Can I perform multi-channel experiments with patch clamp systems?
Yes, patch clamp systems are designed to facilitate multi-channel experiments, allowing you to simultaneously record and analyze electrical activity from multiple cells or channels, making them highly versatile and suitable for various research applications.