Echo® MS+ Systems

Don't compromise - obtain high-quality data, at speed.

Redefine your high-throughput analysis

Combining high data quality and high-throughput analysis

When the quantity of samples is your challenge, break through with the Echo® MS+ system. The Echo® MS+ system gives you high-quality data, analytical flexibility and high sample throughput so you can make informed decisions, today. With sampling rates of up to 1 sample per second, results can be generated on the same day. The Echo® MS+ system is a complete solution that removes bottlenecks in high-throughput analytical workflows, from sample preparation to data reporting.

Choose the right Echo® MS+ system for your laboratory

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The Echo® MS+ system is available in two configurations:

Echo® MS+ system with SCIEX Triple Quad 6500+ system
Echo® MS+ system with ZenoTOF 7600 system offering you the flexibility to meet the needs of your laboratory.

Learn how contactless ejection works

The Echo® MS+ system addresses challenges, such as sample preparation and analysis time, in qualitative and quantitative mass spectrometry analysis.

Redefining high-throughput quantification workflows.

Quality

Deliver high-quality data, minimize sample handling and eliminate carry over with contactless acoustic ejection sampling. Retain the precise, information-rich data needed to make informed decisions about your sample

Precision

Achieve unparalleled standards of quantitation and qualification, at speed. The Echo® MS+ system provides consistency and precision in challenging matrices. Its high specificity enables confidence in results, and both decreases the need for re-runs and saves on reagent costs when compared to other technologies.

Speed

Conquer throughput barriers and decrease overall turnaround time with sampling speeds of up to 1 sample per second. Screen substrate and product simultaneously and reduce the number of analytical steps in your process.

Explore the Echo® MS+ system

Redefining high-throughput quan/qual workflows

01.High-quality data

The Echo® MS+ system is compatible with either the SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system for trusted mass spectrometry performance.

02. Contactless sampling

Sample ejection allows for rapid sampling and reduced carryover.

03. Designed for automation

The system is compatible with robotic automation systems—automating steps such as sample preparation, plate preparation, plate loading/unloading, and plate submission for analysis.

04. Longer operational robustness

The port wash allows for cleaning the electrode assembly between sample plates, increasing the number of ejections that generate high quality data before you need to manually replace consumables.

05. Method flexibility

The new features of SCIEX OS software allow:

Enhanced solvent and additive options for analytical flexibility
Data acquisition modes to enable robust quantitative and qualitative capability
The ability to analyze samples directly from a DMSO matrix

Echo® MS+ system walkthrough

01. Acoustic ejection method

Method setup is both simple and fast. With data acquisition taking as little as 1 sample per second, you can quickly test many options for ideal settings.

02. Mass spectrometer method

The MS method is similar to standard MS systems, with parameters such as mass range or MRM transition needing to be defined. SCIEX OS software users will be familiar with this step.

03. Results

Acquire and process your data in SCIEX OS software, simplifying your workflows and empowering swift, well-informed decision-making.

04. Data collection

See the process from beginning to end

How AEMS takes your analysis to the new level

The Echo® MS+ system uses Acoustic Ejection Mass Spectrometry (AEMS). Samples are placed into compatible microtiter plates that are held in the Echo® MS+ system autosampler. Here, sound energy is applied to the bottom of each well individually. The sound energy causes reproducible droplets to be ejected from the well for capture in a carrier solvent of the OPI for dilution and transfer to the mass spectrometer source. From this point, the diluted sample is ionized using conventional electrospray ionization, making it ready for detection.

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True High Throughput Bioanalysis Using The Echo® MS System

Rapid sample analysis using AEMS technology improves bioanalytical study turnaround

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Rapid Ms/Ms Analysis With Acoustic Ejection Mass Spectrometry (AEMS)

The SCIEX Echo MS System now provides the quantitative ESI MS/MS analysis at the speed of a plate reader with the specificity, linearity and dynamic range of mass spectrometry

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Accelerating Turnaround Time In High-Throughput ADME Pipelines

High-throughput ADME workflows rely on fast turnaround times as these measurements help make informed decisions on potential drug candidates in drug discovery. The Echo MS system with LeadScape Analyze software combines speed of analysis with ease of use to run a 384 well plate in 11 minutes and enable a 50,000 compound campaign to be completed in as low as 24 hours which translates to a 14x TAT improvement when compared to LC-MS/MS analysis.

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Accelerated Pharmacokinetic Profiling And Metabolite Monitoring Using Echo® Ms System

Here, the Echo MS System was used for early discovery phase studies providing DMPK data in seconds as opposed to the hours required when using traditional LC-MRM based scanning methodologies. The system provided highly quantitative data with excellent %CV and accuracy. The workflow also provided clearance information with good agreement between AEMS vs traditional LC-MS as well as high-throughput metabolite monitoring enabling accurate decisions on candidate progression.

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Ultra-Fast, Accurate And Simultaneous Quantification Of Ritonavir And Lopinavir In Human Plasma

Lopinavir and ritonavir are two protease inhibitors (class of anti-viral drugs) often used in a fixed-dose combination, along with other medications, for prevention and treatment of HIV/AIDS. Monitoring of lopinavir and ritonavir in human plasma is needed to ensure proper therapeutic levels are maintained. A very high throughput bioanalytical method (3 sec/sample) for the simultaneous analysis of ritonavir and lopinavir in human plasma is described using the Echo MS platform. Using a simple liquid-liquid extraction (LLE) for sample preparation, the assay provided very sensitive, accurate and reproducible results.

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Up To 10X Increased Throughput For Metabolic Stability Assays

ADME profiling is typically performed on candidates later in the development cycle but performing these screens earlier would provide significant benefits. However, significant gains in sample analysis throughput would be required as the number of compounds to be tested would likely increase by an order of magnitude. Acoustic Ejection Mass Spectrometry (AEMS) on the Echo® MS system is a very high throughput quantitative technique that is ideal for labs performing in vitro ADME. Here using a metabolic stability assay, a ~10x increase in sample throughput was demonstrated when using the Echo® MS system coupled with LeadScape Analyze software as compared to an LC-MS/MS approach.