Harnessing Cutting-Edge Life Sciences Technologies to Accelerate Proteomics Workflows

Proteomics is a powerful tool for identifying, quantifying, and characterizing the proteins expressed in a cell under a set of specific conditions. It can improve our understanding of biological processes and is an essential tool for drug development. Today, proteomics is applied across therapeutic modalities and biopharmaceutical drug development workflows. Regardless of the type of starting sample or proteomic methods used, the right technologies must also be leveraged to optimize sample preparation and data analysis and minimize time-to-data.

The first stage of any proteomics workflow involves sample preparation. Several tedious and time-consuming manual steps required to digest, separate, and purify samples can lead to inconsistencies in data, reduce repeatability, and introduce confounding variables into data. Today, many of these challenges can be solved by leveraging automation. Automating sample preparation and digestion with a Beckman Coulter Life Sciences Biomek i-Series Automated Workstation can reduce hands-on time and increase consistency for proteomics workflows.

Proteomics data acquisition is another major challenge. Improving throughput and data acquisition speeds is key for accelerating bulk proteomics workflows. Advanced instrumentation can enable more informed decision-making. For example, enhanced drug product safety and efficacy measurements can be made with a SCIEX ZenoTOF 7600 Mass Spectrometry system. Other technologies, like Leica Microsystems’ Mica Microhub, automate single-cell proteomics by enabling imaging and sample incubation in a controlled environment.

Individual proteomics workflows are as unique as the research questions we use them to answer. These tools are enabling the discovery of new diagnostic, prognostic, and therapeutic targets for various key diseases. Contact a proteomics expert at Danaher Life Sciences to discover how to optimize your proteomics workflow.