Biologics & Cell Therapy Applications
ChemStress® technology enables both clone & media robustness testing in a small-scale system, early in the process, and in an efficient & data-rich way.
Incubate your cells and/or media with the ChemStress® 96-well plate chemicals and simply use a standard plate reader to measure cell viability and titer in a small-scale simulated production bioreactor environment.
ValitaCell’s R&D team is currently working on the development of the first innovative characterization assay for primary cells and media in the cell therapy space.
CHO Clone Robustness
CHO Media Robustness
Principle of ChemStress® Technology
Clone & Media quality and robustness assessment enabled by ChemStress® allows you to look far beyond the standard quality assurance analytics that relies only on cell viability and titer measurements.
Validate the robustness of your media, select your best media formulation and profile your clones by assessing deep cell functional activity under stressful conditions mimicking known bioprocess stresses and challenging key metabolic pathways in a small-scale model and early in the process.
Cells are challenged with a panel of selected categories of 21 small molecule chemicals challenging key production pathways and mimicking recurrent bioprocess stresses cells are likely to experience in production.
ChemStress® Applications
Media and clone routine testing and characterization are critical during Cell Line Development, through Process Scale-Up and Optimization, and especially before starting and during Manufacturing. ChemStress® can be flexibly integrated into your standard QC testing at any stage providing more confidence to bring forward a specific media lot, the most robust media formulation, or your best clones.
ChemStress® Workflow
Expose cells to stressors Incubate the cells for 72 hours
Measure biological readout (e.g.cell growth and/or titer) with a standard plate reader
Advanced data analysis Rich functional information
Incubate your cells and/or media with the ChemStress® 96-well plate chemicals and simply use a standard plate reader to measure cell viability and titer in a small-scale simulated production bioreactor environment.
How do I empower my process with ChemStress®?
Outsourcing service
Ship your media or clone to our lab and get results.
Run ChemStress® in ValitaCell’s fully optimized automated platform.
In-House service
Get lab and data analysis consultancy service in your lab.
Run ChemStress® in your lab with ValitaCell scientists’ consultancy.