mRNA-based Personalized CRISPR

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Aldevron

IDT

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Research/Discovery

Target Identification

Target validation

Pre-clinical (In-vivo)

Phase I Clinical Trial

Phase II and later Clinical Trials

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In-vivo Gene-Edited Gene Therapy

Ex-vivo Gene-Edited Cell Therapy

Ex-vivo Gene-Modified Cell Therapy

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CRISPR gRNA design and manufacturing (RUO or CGMP)

High-fidelity or modified nucleases

Donor template design and synthesis

IND-enabling regulatory support

LNP

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World’s First mRNA-based personalized CRISPR therapy