Recombinant Human IL-21 (Active) protein
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Recombinant Human IL-21 (Active) protein is a Human Fragment protein, in the 32 to 162 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for FuncS.
View Alternative Names
Interleukin-21, IL-21, Za11, IL21
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Specifications
Form
Lyophilized
General info
Function
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (PubMed : 11081504, PubMed : 15178704). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).
Sequence similarities
Belongs to the IL-15/IL-21 family.
Target data
Product promise
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