ImageXpress® Micro Confocal High-Content Imaging System
Unique confocal imaging solution capable of imaging more than a million wells a week
High-content confocal imaging solution with water objective options
The ImageXpress® Micro Confocal system is a high-content solution that can switch between widefield and confocal imaging of fixed and live cells. It can capture high quality images of whole organisms, thick tissues, 2D and 3D models, and cellular or intracellular events. The spinning disk confocal and sCMOS camera enable imaging of fast and rare events like cardiac cell beating and stem cell differentiation. WithMetaXpress software and flexible options like water immersion objectives to choose from, the system enables many confocal imaging applications from 3D assay development to screening.
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Acquire higher quality images
Capture excellent contrast, high resolution images with our proprietary AgileOptix™ spinning disk confocal technology, wide field of view, and bright light source.
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Customize image acquisition and analysis
Take ultimate control over acquisition and analysis parameters, which enables many applications from 3D structure analysis to target imaging of specific objects within an organism or cell population. Run more applications with standard options like water immersion objectives, environmental control, or any of our high-performance customizations.
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Analyze more data in less time
MetaXpress® PowerCore™ software accelerates analysis speed in a high-throughput environment. The software distributes image processing jobs to a multi-CPU environment.
Features
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Wide dynamic range
Quantify low and high-intensity signals in a single image with >3 log dynamic range intensity detection.
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Exclusive AgileOptix spinning disk confocal
The technology provides increased sensitivity with specially designed optics, high-powered, solid-state light engines, and an sCMOS sensor. Swappable disc geometries provide flexibility between speed and resolution.
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Wide field of view
A wide field of view enables whole-well confocal imaging and eliminates missed targets.
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Optional on-board robotic fluidics
For assays that involve compound addition, well washing, and media exchange, optional onboard robotic fluidics are available.
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Accurate 3D measurements
MetaXpress 3D analysis module is optimized for confocal imaging, enabling 3D measurements of volume and distance.
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Multiple imaging modes
The system offers phase contrast and brightfield label-free imaging, fluorescence, widefield, colorimetric, and confocal imaging, as well as, water immersion imaging as a standard option.
AgileOptix™ technology
Our proprietary AgileOptix technology enables the ImageXpress Micro Confocal system to deliver the sensitivity and throughput needed for demanding applications. AgileOptix is the combination of a powerful solid-state, light engine, specially designed optics, a scientific CMOS sensor, and the ability to change disk geometries.
MetaXpress high-content image aquisition and analysis software
- Meet high throughput requirements with a scalable, streamlined workflow
- Adapt your analysis tools to tackle your toughest problems, including 3D analysis
- Schedule automatic data transfer between third-party hardware sources and secure database
- Set up hundreds of routinely used HCS assays using MetaXpress software modules
Cellular Image Gallery
| Camera Sensor Type | CMOS |
| Cellular Imaging System Type | High-Content Imaging |
| Field of View 10x (Metric mm²) | 1.96 mm² |
| Air Immersion Objectives | 1x, 100x |
| Oil Immersion Objectives | 40x, 60x, 100x |
| Water Immersion Objectives | 20x, 40x, 60x |
| Filter Changer Type(s) | 8 position emission wheel and 5 position dichroic filter wheel |
| Auto Focus Type(s) | Laser+image autofocus |
| Transmitted Light Enabled | Yes |
| Brightfield Enabled | Yes |
| Microplate Size Compatibility | 6 well plate, 12 well plate, 48 well plate, 96 well plate, 384 well plate, 1536 well plate |
| Microscope Slide Compatible | Yes |
| Robotics/Automation Compatible | Yes |
| Includes Temperature Control Compatibility | Yes |
| Widefield Compatible | Yes |
| Imaging Software Compatibility | MetaXpress |
| CO₂ Control Option | Yes |
| Maximum Illumination Channels | 5 |
| 96-Well Plate Scan Time, 2 Colors, 1 Site/Well in Minutes | 2 min |
| Custom Module Editor Capability | Yes |
| Minimum Speed (wells/day) | 200000 wells/day |
| Phase Contrast Capability | Yes |
| Fluidics with Environmental Control Capability | Yes |
| Mobile Data Collection (MDC) Store Data Management Capability | Yes |
| Confocal Capability | Yes |