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ImageXpress® Micro 4 High-Content Imaging System

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Configurable, high-throughput widefield imaging solution for an incredible range of assays

Widefield imaging for basic research through to high-content screening

The ImageXpress® Micro 4 High-Content Imaging System is a high-throughput, widefield imager that can acquire images of whole organisms and cellular or intracellular events. It features proprietary fast frame rate technology, allowing for the capture of fast biological processes such as calcium oscillations in cardiomyocytes. It is highly configurable and adaptable to changing research needs. Available options include confocal, brightfield, phase contrast, liquid handing, and environmental control.

 

Support many cellular assays

Image an incredible range of assays with various user-changeable filter cubes, 1-100x objectives, environmental control, fluidics option, and many sample formats including atypical plates for 3D assays.

Analyze images of more applications

A selection of feature-rich turnkey application modules is available with MetaXpress® software. For the development of novel assays, we offer an optional custom analysis module.

Tailor the system to meet your needs

The imager is a highly flexible solution. You can add or change many of the components as your research priorities change. Examples include enhance light engines and automation.

Features

Multiple imaging modes

The system offers fluorescence, widefield, colorimetric, phase contrast, and brightfield label-free imaging.

Upgradeable to confocal

The system can be upgraded to include the proprietary AgileOptix™ technology for accurate 3D volumetric analyses.

Wide dynamic range

Low and high-intensity signal quantification in a single image with

3 log dynamic range intensity detection.

  • Optional environmental control
  • Temperature, humidity, and CO2 control for multi-day live-cell imaging or fast kinetic studies are available.

High speed image acquisition

Using 4x magnification with a 1536-well plate, 225K wells per day can be acquired. Greater than a million wells per week can be imaged.

Large magnification range

Air and oil immersion objectives ranging from 1x to 100x are available for installation into the 4-position objective changer.

MetaXpress high-content image aquisition and analysis software

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  • Meet high throughput requirements with a scalable, streamlined workflow
  • Adapt your analysis tools to tackle your toughest problems, including 3D analysis
  • Schedule automatic data transfer between third-party hardware sources and secure database
  • Set up hundreds of routinely used HCS assays using MetaXpress software modules

Expand your research using flexible imaging solutions

Molecular Devices provides flexible options for the ImageXpress Micro 4 High-Content Imaging System to meet your research needs and to easily capture images from different sample formats, including hanging drops and in round or flat bottom plates, for monitoring cell health kinetics under environmental control, and more.

Environmental Control

Environmental control maintains temperature and humidity levels while minimizing evaporation for multi-day, live cell, time-lapse imaging.

Transmitted Light Tower

Our transmitted light tower enables acquisition of high contrast images for unstained cells which can be easily viewed or separated from background.

On-Board Robotic Fluidics

Integrated fluidics automates assay workflows which require compound addition, well washing, and media exchange.

Implement a solution that works for you

Molecular Devices can successfully tailor the ImageXpress Micro 4 High-Content Imaging System to include customized software and hardware including the features described herein, as well as integration of other lab components such as incubators, liquid handlers, and robotics for a fully automated workcell. With over 30 years of experience in the life science industry, you can count on us to deliver quality products and provide worldwide support.

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Morphometric characterization of cancer spheroid cultures using confocal imaging and 3D image analysis | Molecular Devices
Learn how confocal imaging can be used to improve performance and throughput of high-content assays with 3D cell models for compound screening and evaluation of anti-cancer drugs.
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Measure Cell Migration using Automated Cell Imaging and Analysis | Molecular Devices
Effectively image and analyze cell migration using a scratch assay or a dissolvable biocompatible gel.
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Increase accuracy and efficiency of cytotoxicity using EarlyTox Live/Dead Assay
This application note describes the use of the EarlyTox Live/Dead Assay Kit in conjunction with the ImageXpress Micro High-Content Imaging System & MetaXpress and high-content imaging system.
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Phenotypic characterization of toxic compound effects on cardiomyocytes derived from induced pluripotent stem cells
Assess cardiotoxicity effects using automated imaging
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Phenotypic Assessment of Toxicity using Human Hepatocyte Co-Culture Model | Molecular Devices
The phenotypic assays have been developed for assessing multi-parameter readouts of general and mechanism-specific hepatotoxicity. Explore this poster for more information.
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ImageXpress Micro 4 High Content Imaging System - Molecular Devices
The ImageXpress Micro 4 High-Content Imaging System is a versatile and efficient imaging solution for research purposes. It offers the option to upgrade to confocal imaging in the future and is compatible with a wide range of assays. The system allows for fast data acquisition and offers various research capabilities. Combined with MetaXpress software, it provides a complete solution for image interpretation and data analysis.
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Evaluating Cell Cycle Inhibitors Using a Live Cell Assay
Evaluation of cell cycle inhibitors using live cell assay with ImageXpress Micro 4.
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Assessment of neurotoxicity and neuronal development using induced pluripotent stem cell-based neurite outgrowth assay | Molecular Devices
This application note describes about the neurotoxicity & neuronal development by using pluripotent stem cell-based neurite outgrowth assay which evaluate & prioritize chemicals for their neurotoxicity potential.