ImageXpress® Micro 4 High-Content Imaging System
Configurable, high-throughput widefield imaging solution for an incredible range of assays
Widefield imaging for basic research through to high-content screening
The ImageXpress® Micro 4 High-Content Imaging System is a high-throughput, widefield imager that can acquire images of whole organisms and cellular or intracellular events. It features proprietary fast frame rate technology, allowing for the capture of fast biological processes such as calcium oscillations in cardiomyocytes. It is highly configurable and adaptable to changing research needs. Available options include confocal, brightfield, phase contrast, liquid handing, and environmental control.
Support many cellular assays
Image an incredible range of assays with various user-changeable filter cubes, 1-100x objectives, environmental control, fluidics option, and many sample formats including atypical plates for 3D assays.
Analyze images of more applications
A selection of feature-rich turnkey application modules is available with MetaXpress® software. For the development of novel assays, we offer an optional custom analysis module.
Tailor the system to meet your needs
The imager is a highly flexible solution. You can add or change many of the components as your research priorities change. Examples include enhance light engines and automation.
Features
Multiple imaging modes
The system offers fluorescence, widefield, colorimetric, phase contrast, and brightfield label-free imaging.
Upgradeable to confocal
The system can be upgraded to include the proprietary AgileOptix™ technology for accurate 3D volumetric analyses.
Wide dynamic range
Low and high-intensity signal quantification in a single image with
3 log dynamic range intensity detection.
- Optional environmental control
- Temperature, humidity, and CO2 control for multi-day live-cell imaging or fast kinetic studies are available.
High speed image acquisition
Using 4x magnification with a 1536-well plate, 225K wells per day can be acquired. Greater than a million wells per week can be imaged.
Large magnification range
Air and oil immersion objectives ranging from 1x to 100x are available for installation into the 4-position objective changer.
MetaXpress high-content image aquisition and analysis software
- Meet high throughput requirements with a scalable, streamlined workflow
- Adapt your analysis tools to tackle your toughest problems, including 3D analysis
- Schedule automatic data transfer between third-party hardware sources and secure database
- Set up hundreds of routinely used HCS assays using MetaXpress software modules
Expand your research using flexible imaging solutions
Molecular Devices provides flexible options for the ImageXpress Micro 4 High-Content Imaging System to meet your research needs and to easily capture images from different sample formats, including hanging drops and in round or flat bottom plates, for monitoring cell health kinetics under environmental control, and more.
Environmental Control
Environmental control maintains temperature and humidity levels while minimizing evaporation for multi-day, live cell, time-lapse imaging.
Transmitted Light Tower
Our transmitted light tower enables acquisition of high contrast images for unstained cells which can be easily viewed or separated from background.
On-Board Robotic Fluidics
Integrated fluidics automates assay workflows which require compound addition, well washing, and media exchange.
Implement a solution that works for you
Molecular Devices can successfully tailor the ImageXpress Micro 4 High-Content Imaging System to include customized software and hardware including the features described herein, as well as integration of other lab components such as incubators, liquid handlers, and robotics for a fully automated workcell. With over 30 years of experience in the life science industry, you can count on us to deliver quality products and provide worldwide support.
| Cellular Imaging System Type | High-Content Imaging |
| Field of View 10x (Metric mm²) | 1.97 mm² |
| Air Immersion Objectives | 1x, 100x |
| Oil Immersion Objectives | 40x, 60x, 100x |
| Filter Changer Type(s) | 5-position filter cube changer |
| Auto Focus Type(s) | Laser+image autofocus |
| Transmitted Light Enabled | Yes |
| Brightfield Enabled | Yes |
| Microplate Size Compatibility | 6 well plate, 12 well plate, 48 well plate, 96 well plate, 384 well plate, 1536 well plate |
| Microscope Slide Compatible | Yes |
| Robotics/Automation Compatible | Yes |
| Includes Temperature Control Compatibility | Yes |
| Widefield Compatible | Yes |
| Imaging Software Compatibility | MetaXpress |
| CO₂ Control Option | Yes |
| Maximum Illumination Channels | 5 |
| 96-Well Plate Scan Time, 2 Colors, 1 Site/Well in Minutes | 2 min |
| Custom Module Editor Capability | Yes |
| Minimum Speed (wells/day) | 200000 wells/day |
| Phase Contrast Capability | Yes |
| Fluidics with Environmental Control Capability | Yes |
| Mobile Data Collection (MDC) Store Data Management Capability | Yes |
| Camera Sensor Type | CMOS |