Echo 650 Plus Series Acoustic Liquid Handlers
- Uses acoustic liquid handling technology to move a wide range of liquids (including DMSO‑based) with sound waves, without physical contact
- Delivers accurate, precise, high‑throughput (up to 700 drops/sec) liquid transfer of nanoliter‑scale quantities as low as 2.5 nL
- Enables complex “any source well to any destination well” combinatorial transfers
- Transfers liquids from 384 well and 1,536 well Echo Qualified microplates, as well as sample tubes* arrayed in a 96-tube format
- Dispenses into any ANSI/SLAS‑compliant dry or pre‑filled 96‑, 384‑, and 1,536‑well microplates (8–16 mm height), as well as select non‑compliant labware
- Supports direct dilution of samples and reagents, including compounds
- Features dynamic machine-learning tools that analyze liquid and plastic characteristics (e.g., DMSO hydration level) and adjust sound‑pulse parameters for optimal transfer quality
- Integrates with other liquid handlers and robotic systems
*Available for tube-enabled models
High‑Throughput, Non‑Contact, Accurate, and Precise Liquid Dispensing with Volumes as Low as 2.5 nL
Building on the trusted foundation of the legacy Echo 650 Series, the new Echo 650 Plus Series elevates acoustic liquid handling with machine‑learning–powered accuracy, a Next Generation Transducer featuring a titanium lens for unmatched stability and advanced electronics that deliver significantly faster real-time computation with dramatically lower power consumption.
Key Features
- Uses acoustic liquid handling technology to move a wide range of liquids (including DMSO‑based) with sound waves, without physical contact
- Delivers accurate, precise, high‑throughput (up to 700 drops/sec) liquid transfer of nanoliter‑scale quantities as low as 2.5 nL
- Enables complex “any source well to any destination well” combinatorial transfers
- Transfers liquids from 384 well and 1,536 well Echo Qualified microplates, as well as sample tubes* arrayed in a 96-tube format
- Dispenses into any ANSI/SLAS‑compliant dry or pre‑filled 96‑, 384‑, and 1,536‑well microplates (8–16 mm height), as well as select non‑compliant labware
- Supports direct dilution of samples and reagents, including compounds
- Features dynamic machine-learning tools that analyze liquid and plastic characteristics (e.g., DMSO hydration level) and adjust sound‑pulse parameters for optimal transfer quality
- Integrates with other liquid handlers and robotic systems
Key Benefits
- Minimizes compound loss, cross-contamination, carryover, or leachates
- Enables assay miniaturization with no loss of data quality
- Reduces reagent costs, plastic waste, and the use of hazardous liquids, while conserving precious samples
- Generates dose‑response and standard curves free from errors commonly introduced by tip‑based liquid handlers and serial dilution
- Accelerates execution of highly complex, multi component assays and experiments
- Enables fully automated custom non-contact liquid handling workflows, including sample transfer from sample storage all the way to assay-ready plates
- Supports ultra-high-density sample storage, preserves sample integrity from storage to screen and rapidly pick sets of samples for targeted screening when using acoustic sample tubes*
*Available for tube-enabled models
Applications
The Echo 650 Plus Series Acoustic Liquid Handlers, like their predecessors, are designed to be used in pharmaceutical and biotech R&D for:
- High-Throughput Screening (HTS)
- Reiterative hybrid deep learning–wet lab screening (OOD discovery)
- Sample Management
- Synthesis-to-Screening (S2S)
- Direct-to-Biology (D2B)
- Assay Development
- Combination/synergistic screens
- Pooled perturbations
- Arrayed functional genomics screens (siRNA/sgRNA/RNP)