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BioLector XT Microbioreactor

The BioLector XT Microbioreactor enables real-time evaluation of biomass, fluorescence, pH, dissolved oxygen in the liquid phase (DO), and other key cultivation parameters for aerobic, anaerobic and phototrophic microorganisms.

BioLector XT Microbioreactor Overview

The high-throughput microbioreactor enables real-time evaluation of biomass, fluorescence, pH, dissolved oxygen in the liquid phase (DO), and other key cultivation parameters for aerobes and anaerobes.

Building on trusted BioLector Pro technology, the BioLector XT Microbioreactor is based on a standard ANSI/SLAS (SBS) microtiter plate (MTP) format, and operates with online, pre-calibrated optical sensors. Disposable 48 well MTPs enable online measurement of cultivation parameters, while patented microfluidic technology supports simultaneous pH control and feeding. The optional microfluidic module eliminates manual liquid handling—no tubing or pipetting required, as everything is part of the gamma-radiated ready-to-use plate.

 

Features of the BioLector XT Microbioreactor

Innovative New Gassing Head

  • Enables fed-batch experiments under anaerobic conditions
  • Gassing with O2 within a range of 1% - 100% and with CO2 within 1% - 12 %
  • Reduces gas consumption to a few mL/minute
  • Optional humidification of gases reduces evaporation

Optional Microfluidic Module

  • Unleashes full potential of the BioLector XT Microbioreactor
  • Complements online monitoring function with well-specific pH regulation/feeding
  • Enables use of 2 reservoir wells per 4 cultivation wells
  • Microvalves allot liquids at nanoliter-scale

“Plug-and-play” Plate Design

  • Real-time kinetics out of 48/32 parallel cultivations
  • Customizable feeding strategies (batch, fed-batch, bolus, continuous)*
  • Control of pH on-the-plate with pre-calibrated optical sensors*
  • Small working volume (800 – 2400 μL)

*Functionality requires optional microfluidic module

Intelligent BioLection Software

  • Intuitive user interface supports multi-user environments
  • Free programming of all control parameters
  • Open system enables live data downloads
  • Fast processor ensures rapid download of experiment data
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BioLector XT Microbioreactor
Microfluidic Bioprocess Control
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Sealing Foil F-RSXT-10
Gas permeable sealing foil with evaporation reduction and perforated silicone layer for the BioLector XT Microbioreactor
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Anaerobic cultivation processes of probiotic bacteria in the BioLector XT microbioreactor
This application note demonstrates the use of the BioLector XT microbioreactor for anaerobic cultivation of probiotic bacteria. It validates the system's effectiveness in maintaining anaerobic conditions, enabling simultaneous pH control, feeding, and direct nitrogen gassing during the cultivation process.
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BioLector Microbioreactor - History and Evolution
This document outlines the history and evolution of the BioLector microbioreactor, from its inception. It highlights key milestones, including the introduction of various BioLector models and their innovative features, emphasizing their impact on high-throughput microbial cultivation and bioprocess optimization.
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mRNA Manufacturing with Fed-Batch In Vitro Transcription
Explore a streamlined fed‑batch IVT workflow from rapid development in the BioLector XT Microbioreactor to scalable production in a ReadyToProcess WAVE™ bioreactor in this collaborative application note from Beckman Coulter Life Sciences and Cytiva.
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Strategic Investment: A Case for Achieving High-Throughput Bioprocessing with the BioLector XT Microbioreactor
Discover how the BioLector XT Microbioreactor can increase your weekly experimental output and efficiency in upstream bioprocessing. This strategic investment offers savings in labor, time, and materials, providing over eight times more data at less than half the total cost compared to traditional benchtop fermenters.