Baloxavir Marboxil(ab286214)

MW 571.6 Da, Purity =99%. A prodrug that is metabolised to the active form baloxavir acid also known as Sâ€033447. Sâ€033447 is a small molecule inhibitor of the capâ€dependent endonuclease of influenza A and B viruses. It has shown nanomolar antiviral activity against influenza A and B viruses in vitro. In murine models of seasonal influenza and avian influenza A(H5N1) or A(H7N9), orally administered baloxavir showed a rapid reduction in pulmonary viral loads and decreased mortality. Baloxavir significantly reduced the time for alleviation of symptoms and reduced virus titres at 24 and 48 hours postâ€treatment at three different doses (10 mg, 20 mg and 40 mg) in a phase II study with patients experiencing uncomplicated influenza.