BMS-986158(ab285435)
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MW 495.6 Da, Purity >=98%. BMS-986158 is a potent bromodomain (BRD) and extra-terminal domain (BET) family inhibitor. BMS-986158 binds to the acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth.
| Shipped At Conditions | Blue Ice |
| Appropriate Long term Storage Conditions | Store at -20°C. |
| CAS Number | 1800340-40-2 |