PF-573228(ab273523)

MW 491.5 Da, Purity >=98%. Potent and selective FAK inhibitor (IC50 = 4 nM versus recombunant catalytic fragent). Blocks FAK Tyr397 phosphorylation in cultured cells (IC50 = 30–100 nM). Shows 50 - 250-fold selectivity for FAK aginst a panel of 40 recombinant kinases. Inhibits chemotactic and haptotactic cell migration.