GDC0879(ab273489)
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MW 334.4 Da, Purity >98%. Potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified V600E enzyme). Inhibits cellular pERK (IC50 = 63 nM). Blocks Raf/MEK/ERK signaling in B-Raf V600E mutant cell lines. Highly selective against a panel of 140 full-length protein kinases.