NU 9056, KAT5 (Tip60) inhibitor(ab255734)

MW 232.4 Da. Selective KAT5 / Tip60 histone acetyl transferase inhibitor (IC50 = <2 μM). Significantly less active towards p300 (IC50 = 60 μM), pCAF (IC50 = 36 μM) and GCN5 (IC50 = >100 μM). Inhibits histone acetylation in prostate cancer cell lines. Inhibits proliferation of a range of prostate cancer cell lines. Induces apoptosis via a Caspase 3- and Caspase 9-dependent mechanism. Modulates epigenetic regulation of cytosolic phospholipase A2 expression in SH-SY5Y cells.