EPPTB, TAAR1 antagonist(ab254331)
$undefined
MW 378.4 Da, Purity >99%. Novel, selective, highly potent trace amine associated receptor 1 (TAAR1) antagonist. Higher potency in mouse than rat and human (IC50 values are 28nM, 4539nM and 7487nM, respectively). Increases firing frequency of dopamine (DA)neurons in ventral tegmental area by blocking inward potassium current mediated by TAAR1, increasing DA activity on D2 receptor. Displays inverse agonism in vitro by reducing cAMP levels (IC50 =19nM).
| Shipped At Conditions | Ambient - Can Ship with Ice |
| Appropriate Long term Storage Conditions | Store at -20°C. |
| CAS Number | 1110781-88-8 |