GW 6471, PPAR alpha antagonist(ab254317)
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MW 619.7 Da, Purity >98%. Potent PPAR alpha antagonist (IC50 = 240 nM). Drives displacement of co-activators from PPAR alpha. Promotes recruitment of co-repressor proteins SMRT and NCoR to ligand binding domain. Inhibits cardiomyocyte differentiation in mouse embryonic stem cells. Causes reduced expression of cardiac sarcomeric proteins and specific genes in a time-dependent manner.
| Shipped At Conditions | Blue Ice |
| Appropriate Long term Storage Conditions | Store at -20°C. |
| CAS Number | 880635-03-0 |