Dolutegravir, HIV integrase inhibitor(ab231511)

MW 419.4 Da. Potent HIV integrase inhibitor (IC50 = 2.7 nM for HIV-1 integrase-catalyzed strand transfer in vitro). Inhibits HIV-1 viral replication (EC50 = 0.51 nM) in peripheral blood mononuclear cells (PBMCs). Prevents replication of several HIV-1 strains (EC50 values of 0.36-2.1 nM) that are resistant to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors.