Elvitegravir, quinolone HIV integrase inhibitor(ab231510)

MW 447.9 Da, Purity >99%. Elvitegravir is an inhibitor of HIV integrase. It inhibits HIV integrase from HIV 1 IIIB (IC50 = 0.7 nM), HIV 2 EHO (IC50 = 2.8 nM) and HIV-2 ROD (IC50 = 1.1 nM) in cell free assays. Elvitegravir blocks integration of HIV cDNA via inhibition of DNA strand transfer. Active against a range of HIV sub-types and against mulit-drug resistant clinical isolates. Potent (IC50 range = 0.21 - 1.15 nM) HIV antiviral activity in various cell-based assays.