abT-263, Bcl-2 family protein inhibitor(ab218114)
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MW 974.6 Da, Purity >98%. Potent, small molecule Bcl-2 family protein inhibitor (Ki's of <1 nM for Bcl-2, Bcl-XL and Bcl-w). Orally bioavailable. Displays anticancer properties. Selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w and disrupts Bcl-2/Bcl-XL interactions with pro-death proteins, leading to the initiation of apoptosis. Induces Bax translocation, cytochrome c release, and subsequent apoptosis.
| Shipped At Conditions | Blue Ice |
| Appropriate Long term Storage Conditions | Store at -20°C. |
| CAS Number | 923564-51-6 |