MLN-4924, NEDD8-activating enzyme inhibitor(AB216470)

MW 443.5 Da, Purity >98%. Potent NEDD8-activating enzyme (NAE) inhibitor (IC50 = 4.7 nM). Selective relative to the closely related activating enzymes ubiquitin-activating enzyme (UAE) and SUMO-activating enzyme (SAE). Adenosine 5'-monophosphate analog. Disrupts cullin-RING ligase (CRL)-mediated protein turnover leading to apoptosis in human tumour cells by deregulating S-phase DNA synthesis.