PIT-1, PIP3/protein binding inhibitor(AB120885)
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MW 351.76 g/mol, Purity >98%. PIP3/protein binding inhibitor. Specifically disrupts PIP3/Akt PH domain binding (IC50 = 31 μM); suppresses PI3K-PDK1-Akt-dependent phosphorylation. Reduces cell viability and induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM). 3,5-Dimethyl PIT-1 (ab120884) also available.
| Shipped At Conditions | Ambient - Can Ship with Ice |
| Appropriate Long term Storage Conditions | Store at +4°C. |
| CAS Number | 53501-41-0 |