Phorbol 12-myristate 13-acetate (PMA), PKC activator(AB120297)

MW 616.8 Da, Purity >99%. Potent nanomolar activator of protein kinase C in vivo and in vitro. Binds to C1 domain of protein kinase C, induces membrane translocation and enzyme activation. Also reported to have actions on non-kinase proteins including chimaerins, RasGRP and Unc-13/Munc-13. Extremely potent mouse skin tumor promoter.