Delve into our comprehensive suite for TOC analysis tailored to meet the stringent demands of pharmaceutical water quality testing and cleaning validation.
Our PAT700 online TOC analyzer designed for pharmaceutical Purified Water and Water For Injection (WFI) incorporates TOC, uncompensated conductivity, and temperature measurements. It ensures a low cost of ownership with 12-month service and calibration intervals. Eliminating the need for chemicals or reagents, this analyzer utilizes a powerful UV lamp for TOC oxidation and ensures reliable oxidation of organics with its UV Detect and UV lamp auto-switching capability.
The analyzer traps an aliquot for each analysis and doesn’t use a peristaltic pump, avoiding the hassle of replacing peristaltic pump tubing or pump heads. The OASIS system (On-Board Automated Standards Introduction System) allows users to analyze grab samples collected from different locations, and to capture water samples in the event of a TOC excursion, enhancing the analyzer's support for root-cause analysis.
This analyzer’s user-friendly features include built-in electronic automated calibration and System Suitability standard operating procedures (SOPs) with automated pass/fail calculations, guiding users step-by-step through the entire analysis process with on-screen visuals and prompts.
The OASIS system can be equipped with RFID, simplifying bottle loading is facilitated by RFID tags on calibration and system suitability standards, featuring certified value data and use-by dates. The TOC analyzer reads the RFID tags, issues warnings for incorrect loading or expired standards, conducts tests, and automatically generates pass/fail results along with detailed reports. Experience the reliability, efficiency, and compliance-enhancing capabilities of our online PAT700 TOC analyzer.
Our QbD1200+ Laboratory TOC analyzer is a versatile benchtop analyzer optimized for Purified Water, WFI and cleaning validation. It delivers the highest performance with unparalleled ease of operation and maintenance and can be completed with an autosampler for fully unattended operation.
Reliable data is ensured with the Nondispersive Infrared (NDIR) sensor that automatically corrects background and drift for long-term stability. The dynamic endpoint detection ensures complete removal of inorganic carbon and complete oxidation of organics. Low cost of ownership is ensured with one reagent only for all analysis and with a 12-month service interval. The Laboratory TOC Analyzer continuously monitors all critical parameters and stops analysis and reports an on-screen alarm if any critical parameters fail. It also continuously monitors UV light intensity, reagent, carrier gas, NDIR sensor, Peltier cooler and dispense module performance. The system uses a large 10.4-inch color touchscreen display and intuitive user interface that guides operators through the different steps of the analysis.
Features
Essential Features of our Online TOC Analyzers
- Seamless integration of TOC, uncompensated conductivity, and temperature measurements into a single device, offering a comprehensive solution for water quality analysis.
- Compliance with industry standards, it meets the requirements of USP<643>, JP <2.59>, EP 2.2.44 for TOC and USP<645> for conductivity.
- Full oxidation of the organic matter is ensured by end-point detection and provides the most accurate TOC result, making the system a highly reliable TOC analyzer.
- Support root-cause analysis with automatic capture of water samples during TOC excursions, aiding in the identification and resolution of potential issues.
- Low cost of ownership with 12-month service and calibration intervals, providing a cost-effective solution for pharmaceutical water quality monitoring.
- No chemicals or reagents required; A UV lamp ensures oxidation of the organic matter, minimizing operational complexities and ensuring a streamlined analytical process.
- Flexibility with the OASIS system allowing analysis of grab samples and facilitating calibration and System Suitability Test.
- Data integrity and 21 CFR part 11 support with multi-level username and password protection to safeguard sensitive information, and audit trail.
Features
Essential Features of our Laboratory TOC Analyzers
- TOC analysis for water quality analysis and for cleaning validation.
- Compliance with industry standards, it meets the requirements of USP<643>, JP 16 <2.59>, and EP 2.2.44 for TOC.
- Full removal of the inorganic carbon and full oxidation of organics is ensured by the end-point detection NDIR sensor.
- Low cost of ownership with 12-month service and calibration intervals, and a single reagent for all analysis, providing a cost-effective solution for TOC analysis.
- One reagent only for the removal of inorganic carbon and for the oxidation of organics, along with a UV lamp for TOC oxidation, minimizing operational complexities and ensuring a streamlined analytical process.
- Flexibility, with manual analysis or fully automated operation with the autosampler that accommodates 64 sample vials for unattended operation, simplifying workflows in QC laboratories.
- Data integrity and 21 CFR part 11 support with multi-level username and password protection to safeguard sensitive information and audit trail.
Applications
Applications of Total Organic Carbon Analyzers
- Online pharmaceutical water quality testing: Purified Water, Water For Injection (WFI)
- Clean-In-Place (CIP) processes
- At line or laboratory pharmaceutical water quality testing
- Cleaning validation
How is TOC measurement used in the context of process control?
TOC measurement in process control helps monitor the organic matter content in water or other substances. This information is vital for maintaining product quality, complying with regulations, and optimizing processes to prevent contamination or undesired chemical reactions.
Can TOC analyzers be used for continuous monitoring?
Yes, TOC analyzers are well-suited for continuous monitoring, providing real-time measurement of organic matter levels in diverse applications such as drinking water, ultrapure water in microelectronics, and various water treatment processes. Their capability for continuous TOC monitoring makes them indispensable for ensuring water quality and regulatory compliance in dynamic water applications.
Are our online TOC analyzers suitable for pharmaceutical applications?
Yes, our TOC analyzers are highly suitable for pharmaceutical applications, featuring industry-leading capabilities in the calibration and measurement of TOC and conductivity for water monitoring. Thanks to the online measurements, our analyzers ensure precise assessment, making them ideal for the monitoring of production for Purified Water and WFI, and for Clean-In-Place processes.
Are our online TOC analyzers suitable for CIP processes?
Yes, our online TOC analyzers are highly suitable for CIP applications. They offer a special Clean-In-Place mode combining conductivity and TOC measurements on the Water For Injection (WFI) used during the final rinse to ensure that the process vessel's final rinse water is free from both inorganic and organic matter, meeting the quality level of WFI.
Is our laboratory TOC analyzer able to accurately analyze different types of samples in a single batch?
Yes, our laboratory TOC analyzer can analyze samples with a large range of TOC concentrations in a single batch. The endpoint detection ensures full removal of the inorganic carbon before starting the oxidation of the organic matter. The endpoint detection also ensures that all the organic matter is oxidized and measured before completing the analysis. To prevent sample-to-sample carryover, the glass reaction chamber is flushed out after each measurement and the system features autorange and sample dilution capabilities to automatically assess and dilute samples when needed.