Liquid Chromatography (LC) Columns
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We offer a diverse range of liquid chromatography (LC) columns with cutting-edge technology, such as HPLC, UHPLC, adsorption liquid chromatography, capillary liquid chromatography, automated liquid chromatography, supercritical fluid chromatography, guard columns, etc. These liquid chromatography columns offer solutions a variety of scientific laboratories, such as pharmaceuticals, food science, etc., for the separation and analysis of complex mixtures.
Elevate your analytical capabilities with faster LC analysis with our advanced columns for liquid chromatography, ensuring optimal sensitivity and precision in your analyses. Our LC columns, essential for separating and quantifying compounds based on their chemical properties, are available in various formats, from nano to analytical UHPLC to preparative, these column ensure compatibility with a wide range of instruments for method execution. Our nano columns featuring integrated fittings were specifically engineered to seamlessly work with a wide range of currently available systems in liquid chromatography labs, offering a user-friendly fitting that ensures reliable connections by preventing both over-tightening and under-tightening, guaranteeing leak-free performance. Our guard columns used in liquid chromatography are designed to effectively (and inexpensively) safeguard your valuable chromatography columns from the damaging effects of chemical contaminants without altering your chromatographic results. Our  UHPLC columns  allow you to dramatically enhance efficiency and achieve extraordinary resolution results in your separations on any system as a leading provider in the UHPLC field. We provide an extensive array of solid supports, encompassing core-shell, organo-silica fully porous, and thermally modified fully porous particles, all available in a micro-LC format. Our analytical LC columns, essential for separating and quantifying compounds based on their chemical properties, are available in various formats, from nano and UHPLC to prep, ensuring compatibility with a wide range of instruments for method execution. Guaranteed to be the longest-lasting  preparative LC columns available, our advanced column packings and hardware come in over 40 distinctive achiral and chiral selectivities, offering enhanced performance through increased sorbent bed density while eliminating media bed collapse as a source of premature column failure.
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Features

Essential features

  • The nano column featuring integrated fitting provides a tactile "CLICK" confirmation upon finger-tightening, ensuring consistent and precise connections while preventing over- or under-tightening that could otherwise impact column performance.
  • Enhancing the durability of LC columns, the guard cartridge prevents system pressure spikes by intercepting and accumulating contaminants and particulates, allowing users to replace the cartridge rather than the column itself, prolonging the column's operational lifetime and maintaining peak performance.
  • Demonstrating exceptional quality, our UHPLC columns feature innovative, fully porous, and core-shell particle designs, consistently delivering extraordinary resolution results across various separation systems.
  • Due to the consistent pressure applied to the integrated packing piston, preparative LC Columns maintain a dynamically stable and uniform media bed, ensuring superior column performance regardless of the chosen media selectivity.

Applications

Applications of Liquid Chromatography Columns

  • Used in  chiral HPLC, our LC columns help separate and analyze enantiomers of chiral compounds in drug development and quality control.
  • Our LC columns, used in gel filtration or size-exclusion chromatography, help separate and purify proteins and protein complexes in the biopharmaceutical industry, ensuring the isolation of high-quality, biologically active molecules for therapeutic applications.
  • In HILIC (hydrophilic interaction liquid chromatography) for analyzing polar metabolites in biological samples, our LC columns allow the separation and quantification of a wide range of water-soluble compounds in metabolomics and pharmaceutical research.
  • In ion-exchange chromatography our LC columns are extensively employed for the purification of complex protein mixtures, enabling the separation of positively charged proteins in cation-exchange and negatively charged proteins in anion-exchange.
  • The use of our LC columns in ion-exclusion chromatography helps separate components using an ion-exchange resin to exclude highly ionized particles while retaining slightly ionized or non-ionized particles. This makes them valuable in drug formulation, food quality control, and bioethanol production monitoring.
  • In antisense oligonucleotide purification, our columns are employed for filtering oligonucleotides from post-synthesis solutions, while in mRNA development, we offer methods to facilitate comprehensive mRNA analytical testing for understanding the final drug product.
FAQs

What are the different types of liquid chromatography techniques we offer?

  • Flash chromatography:  This technique utilizes gravitational force to expedite the purification of compounds by propelling liquid mobile phases through a column filled with stationary phases.
  • HPLC or high-performance liquid chromatography:  This employs high-pressure pumps to separate and quantify constituents within liquid mixtures.
  • Large-scale column chromatography:  This is employed to separate and isolate substantial quantities of target compounds from complex mixtures.
  • Preparative HPLC:  This uses HPLC to isolate and collect larger quantities of specific compounds, facilitating further analysis.
  • UHPLC: This represents a rapid and high-resolution variation of HPLC, enhancing both separation efficiency and speed.

How do I choose the right LC column?

Right liquid chromatography column selection is crucial for the success of your liquid chromatography (LC) analysis, especially in liquid chromatography-tandem mass spectrometry (LC-MS/MS) applications like Glyphosate LC-MS and Ammonium acetate LC-MS. To simplify your choice, consider key factors such as analyte characteristics, the composition of the mobile phase, and desired separation outcomes. Our LC column selection guide and tools like the LC column volume calculator and LC column conditioning, empower you to optimize LC column selection effortlessly, ensuring accurate LC-MS data analysis for small molecules like antibiotics, statins, etc. Crafted by experts with a deep understanding of chromatography, our LC columns are meticulously engineered to harness the advantages of liquid chromatography, effectively addressing the requirements of diverse industries and catering to a wide range of LC-MS applications, such as amino acid, peptide, and oligonucleotide analysis.

What are the differences between gas chromatography (GC) and liquid chromatography (LC)?

GC and LC are separation techniques where GC employs a gaseous mobile phase, making it ideal for volatile compounds, while LC uses a liquid mobile phase, suitable for a broader range of analytes, and the choice between them depends on specific analytes, separation needs, detection requirements, and applications, highlighting the differences between  gas chromatography vs. liquid chromatography.