Streamlining 3D Cancer Assays with Automated Innovations

Facilitating Discovery

The search for new and effective therapies involves navigating through a vast landscape of molecular possibilities to discover compounds that can target and treat complex diseases, such as cancer. Difficult cancer phenotypes often require researchers to seek multiple drugs that can act synergistically. Finding effective drug combinations for complex cancers is challenging.

Getting to know the efficacy of drugs or their combinations early during the drug discovery process is vital for the success of clinical trials and subsequent patient care. A clear understanding of organ toxicity linked to drugs or drug combinations in the early phases of drug discovery can help inform clinical outcomes.

For this, 3D cultured cancer models are proving to be immensely valuable, since they replicate the intricacies of a tumor microenvironment. Nevertheless, there are significant hurdles in executing 3D assays for screening cancer drugs. Maintaining 3D cell cultures is not only onerous but also requires hands-on involvement and precise monitoring.

Automating the process of cell culture can simplify the maintenance of 3D cancer models and improve the quality and reproducibility of 3D cell culture-based assays for drug screening. Automated systems, such as Molecular Devices’ CellXpress.ai Automated Cell Culture System can help make drug screening workflow more robust and reproducible. This cell culture and imaging system streamlines complex workflows, including cell culture, assay set-up, screening, and data analysis.

Powered by imaging and AI-powered image analysis, it continuously monitors 3D cell cultures and automates assays for extended workflows. This minimizes hands-on time, enabling labs to efficiently maintain and scale up complex 3D cell-based assays. Besides offering predictive capabilities for developing precise cancer treatments, this enhances reproducibility and precision during drug discovery.

Take the leap

Elevate your 3D biology experiments with the power of automation and accelerate the development of life-changing therapies. Contact an expert at the Life Sciences companies of Danaher to know more about solutions that can transform your workflows.