Eliminating Analytical Bottlenecks and Streamlining Drug Discovery

Advanced analytical methods have become indispensable in drug development pipelines. Accurate analytical data provides crucial insights for informed decision making, ensuring that the development of life-changing therapies is supported by repeatable data. For example, mass spectrometry (MS) as an analytical method is indispensable in defining critical quality attributes (CQAs) of pharmaceutical products, such as mass, peptide composition, and biological potency. Likewise, flow cytometry is essential for understanding CQAs for validating antigen binding or the correct cellular phenotype.

However, as processes such as analytical sample preparation and instrumentation become faster and more high-throughput, the downstream surge in complex data becomes increasingly challenging to manage, necessitating additional time and expertise from skilled scientists. Take for instance, the amount of time and effort required to manually analyze large volumes of complex data obtained from in-depth mass spectrometric studies.

Innovative instrumentation can allow more in-depth studies and researchers can look forward to obtaining high volumes of information in minimal time. However, scientists also need to act on these volumes of data – protein ID workflows within SCIEX OS software allow researchers to not only identify the protein groups and precursors swiftly with the aid of in silico libraries, but also accurately quantify protein groups, enhancing productivity, and streamline drug candidate screening. By using an in silico-generated library, SCIEX’s Zeno SWATH DIA method eliminates the need to build spectral libraries from scratch, improving the speed of experimental runs.

Data bottlenecks during drug development can significantly diminish the gains accrued from the automation of analytical methods. Unlock the potential of your laboratory by tapping into solutions that consider all facets of complex workflows, encompassing instrumentation, software, and optimized methods. To learn more about these solutions, contact an expert at the Life Sciences companies of Danaher today.