Streamlining Cell Line Development with Integrated Automation

Cell Line Development (CLD) is essential in the journey to groundbreaking therapeutic products. The careful selection of cell lines significantly shapes the later phases of development, ensuring the quality and efficacy of the end products. A finely tuned CLD process ensures the consistent generation of pre-qualified, high-yielding cell lines, enhancing manufacturing efficiency by reducing waste and operational costs while accelerating time to market.

The push to accelerate the CLD process emphasizes the need for robust processes and advanced automation. This can bring significant benefits, paving the way for seamless workflows:

• Optimize infrastructure utilization – Ensures efficient use of available resources.
• Improve quality and consistency – Reduces errors and variability associated with manual tasks.
• Enhance scalability and throughput – Supports growing demands and high-volume workflows

Making automation a cornerstone of the CLD process enables researchers to unlock new possibilities, accelerating the path to groundbreaking life-saving treatments.

Automating Colony Picking Workflows

Historically, clone selection within CLD has presented a formidable challenge:

• Manual Methods

  • Low throughput
  • Time-consuming, labor-intensive
  • High susceptibility to human errors

• Automated clone selection

  • Enables precise, high-throughput screening
  • Focuses on isolating high-value clones
  • Manages a large number of clones efficiently and rapidly

The commitment to ensuring monoclonality and a steadfast focus on accuracy and consistency becomes critical for adhering to regulatory standards and achieving product uniformity. Automated clone selection not only advances the efficiency of the CLD process but also reinforces the integrity and reliability of the resulting product.

Automating Cell Line Development

Integrated workstations are crucial in automating a significant part of the CLD process, addressing resource bottlenecks and ensuring consistency and accuracy.

To meet the demand for high-throughput screening and prevent contamination, integrated workstations equipped with:

• Liquid handlers – Automated precise reagent dispensing and reduce manual errors.
• Incubators – Maintain optimal environmental conditions for cell growth.
• Centrifuges – Enable rapid sample processing and separation.
• Colony pickers – Streamline the selection of high-performing clones.
• Cell analyzers - Provide real-time data for informed decision-making.

These instruments work together to fully automate cell culture and sample preparation, improving efficiency and maintaining sterility. By reducing the need for human intervention, these systems enable faster progression from initial cell transfection to final clone selection. The resulting efficiency gains and improved throughput are essential for the development of therapeutic biologics.

To learn more about the full potential for acceleration and transforming CLD during drug development, contact an expert from the Life Sciences companies of Danaher today.