Insights into disease states with automated NGS library prep

Next-generation sequencing (NGS) has a transformative role in the field of drug discovery. Its ability to provide unprecedented insights into the molecular landscape of a variety of diseases, such as identifying upregulated or downregulated genes in the tumor microenvironment , enables researchers to better understand disease states. Additionally, NGS allows researchers to screen for intended genetic modifications in samples or to check for off-target modifications during CRISPR-mediated gene editing. Fundamental to the process of NGS is the preparation of a library of RNA or DNA samples for gene sequencing.

Advancing science, propelling discovery

While sample library preparation for NGS can be done manually, the process is often imprecise and error-prone, resulting in poor sequencing data. Automating NGS library preparation is important to achieve higher throughput and confidence in data. Automation solutions like the Beckman Coulter Life Sciences Biomek i-Series Automated Liquid Handle make it easier for researchers and clinicians to obtain quality libraries for further analysis. Not only does this improve throughput and accuracy during NGS across a variety of sample inputs, but also significantly reduces hands-on time during sequencing.

Library preparation protocols are time-consuming to execute and can take a lot of time despite automation. By reducing volume requirements and enabling highly accurate and contactless dispensing of liquids during NGS library preparation, the Beckman Coulter Life Sciences Echo Acoustic Liquid Handler can enable time savings and expedite NGS workflows. Utilizing an Echo can result in time savings of nearly 82% during gene assembly and NGS validations, compared to traditional liquid handlers.

By embracing the transformative precision of automation for NGS library preparation, these revolutionary solutions can alleviate the time-consuming intricacies of the process, propelling drug discovery and development processes forward with better NGS data. To understand more how our solutions are helpful in advancing science through discovery, contact an expert at the Life Sciences companies of Danaher Corporation today.