Ultra-High Throughput Screening (uHTS) is a method used in drug discovery to screen millions of compounds at a time for potential therapeutic activity. uHTS involves using automated methods to test many compounds at once in order to identify those that have a desired biological effect.

Primary screening is the first stage in uHTS, in which large numbers of compounds are screened against a target molecule or biological system to identify those that exhibit a desired level of activity. The goal of primary screening is to quickly identify compounds that may show potential to be developed into drugs.

Compounds that pass primary screening criteria advance to secondary screening. Hits identified are stringently tested to understand their mechanism of action and specificity. The secondary screening process may involve additional experiments or assays to further evaluate the compounds and determine their suitability for downstream development.

uHTS requires sophisticated and integrated automated liquid handling and analytical capabilities. Our Danaher Life Sciences companies provide a wide range of custom solutions and fit-for-purpose technologies for assembling uHTS workstations.